Temporal Stability of Heavy Drinking Days and Drinking Reductions Among Heavy Drinkers in the COMBINE Study.

Author: AntonRaymond F, FalkDaniel E, HallgrenKevin A, HasinDeborah S, KranzlerHenry R, LittenRaye Z, MannKarl F, O'MalleyStephanie S, PearsonMatthew R, WilsonAdam D, WitkiewitzKatie

Paper Details 
Original Abstract of the Article :
Recently, the Food and Drug Administration (FDA) proposed to expand the options for primary end points in the development of medications for alcohol use disorder to include either abstinence from alcohol or a nonabstinent outcome: no heavy drinking days (with a heavy drinking day defined as more tha...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/28295414

データ提供:米国国立医学図書館(NLM)

Stability of Drinking Reductions: A Look at the COMBINE Study

The field of addiction research is constantly seeking new and effective treatments for alcohol use disorder. This study examines the temporal stability of heavy drinking days and drinking reductions among heavy drinkers participating in the COMBINE Study. The study's findings suggest that the Food and Drug Administration (FDA)'s proposed expansion of primary end points in clinical trials to include no heavy drinking days, as an alternative to abstinence, could be a valuable approach to assessing treatment effectiveness. The researchers found that nonheavy drinking outcomes were stable over time, providing evidence for the validity of this nonabstinent outcome measure.

Measuring Success Beyond Abstinence

This research challenges the traditional focus on abstinence as the sole measure of success in treating alcohol use disorder. The findings suggest that a reduction in heavy drinking days, even in the absence of complete abstinence, can be a meaningful outcome. This shift in perspective could lead to more effective treatment approaches and more realistic goals for individuals struggling with alcohol use disorder.

Supporting Recovery

This study highlights the importance of providing a range of treatment options that cater to individual needs and goals. For some individuals, complete abstinence may be the most appropriate goal, while for others, reducing heavy drinking days may be a more achievable and sustainable path to recovery. It is crucial to work with individuals to develop personalized treatment plans that support their individual needs and goals.

Dr.Camel's Conclusion

This study's focus on the stability of nonheavy drinking outcomes is a welcome addition to the field of addiction research. It reminds us that recovery is a journey, not a destination, and that progress can be measured in different ways. Just as the camels navigate the vast desert, individuals with alcohol use disorder can find their own unique paths to recovery.

Date :
  1. Date Completed 2018-02-21
  2. Date Revised 2019-01-12
Further Info :

Pubmed ID

28295414

DOI: Digital Object Identifier

NIHMS858785

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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