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Challenges for achieving safe and effective radical cure of Plasmodium vivax: a round table discussion of the APMEN Vivax Working Group.

Author: AbeyasingheRabindra, AktaruzzamanMohammad M, AlamMohammad Shafiul, AuburnSarah, BairdJ Kevin, BarryAlyssa, BattleKatherine, BhowmickIpsita Pal, BibitJo-Anne, BoazLeonard, BobogareAlbino, ChengQin, ChinanonwaitNipon, CommonsRobert, Da ThakurGarib, DanansuriyaManjula N, DerayRaffy, DevineAngela, DingXavier C, Do ManhHa, DomingoGonzalo J, DrukpaTobgyel, DucThang Ngo, DuparcStephan, DysoleyLek, GuodingZhu, HongYoung S, HowesRosalind E, JambertElodie, KanekoAkira, KenangalemEnny, KhanWasif Ali, KitchakarnSuravadee, KusriastutiRita, LeeSang-Eun, LeyBenedikt, MakitaLeo Sora, MarfurtJutta, McCarthyJames, MiottoOlivo, MudinRose Nanti Binti, MudiyanselageSantha D, NaketEsau, NambanyaSimone, NamgayRinzin, NausienJohnny, NguitragoolWang, NoviyantiRintis, OunekhamSonesay, PasaribuAyodhia P, PriceRic N, QiGao, RichardsJack S, Roca-FeltrerArantxa, RoobsoongWanlapa, SamadIriani, SarawatiElvieda, SattabongkotJetsumon, SatyagrahaAri, SharmaSurender Nath, SibleyCarol H, SintasathDavid, SohelNayeem, Swe PhruChing, TheodoraMinerva, ThriemerKamala, von SeidleinLorenz

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This meeting report summarizes the key discussion points from a round table discussion on the programmatic issues hindering the widespread use of primaquine (PQ) for radical cure of Plasmodium vivax malaria. The discussion highlighted the need for robust point-of-care (PoC) glucose-6-phosphate dehydrogenase (G6PD) tests and strategies to improve adherence to PQ regimens.
Paper Details　
Original Abstract of the Article :
The delivery of safe and effective radical cure for Plasmodium vivax is one of the greatest challenges for achieving malaria elimination from the Asia-Pacific by 2030. During the annual meeting of the Asia Pacific Malaria Elimination Network Vivax Working Group in October 2016, a round table discuss...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382417/

データ提供：米国国立医学図書館（NLM）

The Challenge of Eradicating *Plasmodium vivax* Malaria

Malaria elimination is a global health priority, and the fight against *Plasmodium vivax* is particularly challenging. This research delves into the complexities of achieving a safe and effective radical cure for *Plasmodium vivax* malaria, a crucial step in the fight against malaria elimination in the Asia-Pacific region by 2030. The study examines the programmatic hurdles that hinder the widespread use of primaquine (PQ) radical cure, a crucial medication for eliminating the dormant stage of the parasite. The study highlights the importance of robust point-of-care (PoC) G6PD tests for diagnosing glucose-6-phosphate dehydrogenase (G6PD) deficiency, a condition that can lead to severe side effects from primaquine. The researchers also emphasize the need for affordable, accessible, and user-friendly G6PD tests accompanied by comprehensive training programs for healthcare professionals. The study concludes that effective treatment practices are essential for widespread deployment of radical cure strategies, ensuring that the benefits outweigh the risks for both patients and the community.

The Importance of Accessible G6PD Testing

The study underscores the critical need for accessible and reliable G6PD testing as a prerequisite for effective radical cure strategies. This is crucial for ensuring that patients who are G6PD deficient can be identified and treated appropriately, minimizing the risk of adverse reactions to primaquine.

Impact on Individual Health and Public Health

The availability of accessible and affordable G6PD tests can have a profound impact on both individual health and public health. It can help prevent severe and potentially life-threatening side effects associated with primaquine treatment in G6PD deficient individuals. By ensuring the safe and effective use of primaquine, it can contribute to the overall success of malaria elimination efforts.

Dr. Camel's Conclusion

Think of it this way: Imagine a vast desert, and the *Plasmodium vivax* parasite is a hidden oasis, waiting to resurface and cause trouble. Primaquine is the key to reaching that oasis and drying it up, but we need to make sure we don't end up dehydrated ourselves! This research highlights the importance of careful navigation to ensure that the cure doesn't become a bigger problem. We need reliable G6PD testing to navigate these treacherous landscapes and safely eradicate *Plasmodium vivax*.

Date :
  1. Date Completed 2017-06-08
  2. Date Revised 2023-01-11
Further Info :

Pubmed ID

28381261

DOI: Digital Object Identifier

PMC5382417

SNS
PICO Info
in preparation
Languages

English

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