Neoadjuvant treatment in pancreatic cancer: Evidence-based medicine? A systematic review and meta-analysis.

Author: AntolinoLaura, AurelloPaolo, D'AngeloFrancesco, De SienaMartina, FarcomeniAlessio, Kazemi NavaAndrea, NigriGiuseppe, PetruccianiNiccolò, RamacciatoGiovanni, SirimarcoDario, ValabregaStefano

Paper Details 
Original Abstract of the Article :
Neoadjuvant treatment in non-metastatic pancreatic cancer (PaC) has the theoretical advantages of downstaging the tumor, sterilizing any present systemic undetectable disease, selecting patients for surgery and administering therapy to each patient. The aim of this systematic review is to analyze th...See full text at original site
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引用元:
https://doi.org/10.1007/s12032-017-0951-0

データ提供:米国国立医学図書館(NLM)

The Shifting Sands of Pancreatic Cancer Treatment: A Meta-Analysis of Neoadjuvant Therapy

Navigating the complex world of pancreatic cancer treatment is like traversing a vast desert, where the path to recovery is often obscured by uncertainty. This research delves into the use of neoadjuvant therapy – a treatment approach that combines surgery and chemotherapy – for pancreatic cancer, exploring its effectiveness and potential benefits.

Examining the Oasis of Hope: A Comprehensive Review of Neoadjuvant Treatment for Pancreatic Cancer

The researchers conducted a meta-analysis of 12 studies, meticulously combing through the scientific literature to assess the efficacy of neoadjuvant treatment for pancreatic cancer. They analyzed data from over 600 patients, examining various treatment strategies and their impact on overall survival. The study revealed that neoadjuvant approaches are becoming increasingly common, offering potential benefits for resectable, borderline resectable, and locally advanced pancreatic cancer.

Seeking a Clear Path Through the Desert: Understanding the Challenges and Benefits of Neoadjuvant Therapy

The study also found that while neoadjuvant therapy appears to offer better outcomes compared to other treatment approaches, robust evidence remains limited. Think of it as finding a promising trail in the desert, but needing further exploration to confirm its reliability. The authors advocate for a more rigorous approach, emphasizing the need for randomized clinical trials to definitively determine the long-term efficacy of neoadjuvant therapy for pancreatic cancer.

Dr. Camel's Conclusion

This research is a vital step in our quest to conquer pancreatic cancer. While the path to a cure remains long and arduous, this study illuminates potential avenues for improving patient outcomes. It's a reminder that we must always strive for a deeper understanding of this complex disease and explore all possible approaches to ensure the best possible treatment for our patients.

Date :
  1. Date Completed 2017-04-19
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28391577

DOI: Digital Object Identifier

10.1007/s12032-017-0951-0

Related Literature

SNS
PICO Info
in preparation
Languages

English

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