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Ketoprofen-loaded Eudragit electrospun nanofibers for the treatment of oral mucositis.
Author: El-KamelAmal Hassan, RedaRana Ihab, WenMing Ming
Original Abstract of the Article :
PURPOSE: The purpose of this study was to formulate ketoprofen (KET)-loaded Eudragit L and Eudragit S nanofibers (NFs) by the electrospinning technique for buccal administration to treat oral mucositis as a safe alternative to orally administered KET, which causes gastrointestinal tract (GIT) side e...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376182/
データ提供:米国国立医学図書館(NLM)
Ketoprofen Nanofibers: A New Approach to Treating Oral Mucositis
Oral mucositis, a painful inflammation of the mouth lining, is a common side effect of cancer therapies, significantly impacting patients' quality of life. Conventional treatments for oral mucositis can have unwanted side effects, such as gastrointestinal problems. This study explored a novel approach using ketoprofen-loaded Eudragit nanofibers for buccal administration, aiming to deliver the medication directly to the affected area while minimizing systemic exposure.
The researchers successfully formulated ketoprofen-loaded Eudragit nanofibers that demonstrated promising results in both in vitro and in vivo studies. The nanofibers effectively suppressed the inflammatory response associated with mucositis in rabbits. This innovative approach suggests a potential alternative to traditional oral delivery of ketoprofen, with the potential to reduce systemic side effects and improve the management of oral mucositis.
Nanotechnology in Medicine: A New Desert Oasis
Nanotechnology is revolutionizing medicine, offering new solutions to age-old challenges. These ketoprofen-loaded nanofibers, like a refreshing oasis in a vast desert, provide a targeted and potentially safer approach to treating oral mucositis. This innovative technology could improve the lives of many cancer patients, offering a more comfortable and effective treatment option.
A New Approach to Oral Mucositis: A Smoother Journey
Oral mucositis can be a challenging and painful condition, like navigating a scorching desert. This study highlights the potential of nanotechnology to create a smoother and more comfortable journey for patients. By delivering medication directly to the affected area, these ketoprofen-loaded nanofibers may reduce systemic side effects and improve the overall treatment experience.
Dr.Camel's Conclusion
Ketoprofen-loaded nanofibers are like a caravan of camels carrying relief across the vast desert of oral mucositis. This innovative approach promises a more targeted and potentially safer treatment, offering a smoother and more comfortable journey for patients suffering from this debilitating condition.
Date :
- Date Completed 2017-05-22
- Date Revised 2022-03-17
Further Info :
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