Paper Details

  1. Home
  2. Paper Details

[Application of synthetic and semisynthetic polymers (Kollidon K30 and hydroxypropylmethylcellulose) as carriers of ketoprofen in solid oral prolonged-release dosage forms].

Author: KotMateusz, KołodziejczykMichał, LinkaWojciech

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the suitability of polymers (Kollidon K30 and hydroxypropyl methylcellulose) and calcium hydrogen phosphate dihydrate as fillers for the construction of matrices for solid oral dosage forms containing ketoprofen. The study found that formulations containing hydroxypropyl methylcellulose and calcium hydrogen phosphate dihydrate resulted in prolonged release of ketoprofen, while Kollidon K30 accelerated release. This suggests that hydroxypropyl methylcellulose and calcium hydrogen phosphate dihydrate may be useful for developing prolonged release formulations of ketoprofen.
Paper Details　
Original Abstract of the Article :
BACKGROUND: One of the most important challenges of the modern technology of solid oral dosage forms is to increase the effectiveness of the drug, reduce side effects and improve the comfort of use. One way to obtain such effects are prolonged release dosage forms. OBJECTIVES: The aim of the study ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.17219/pim/69296

データ提供：米国国立医学図書館（NLM）

Prolonged-Release Dosage Forms of Ketoprofen

The development of [prolonged-release dosage forms] is a crucial area of research in [pharmaceutical science] as it allows for more controlled and sustained drug delivery, potentially improving patient outcomes and reducing side effects. This study explores the suitability of different polymers as carriers for [ketoprofen], a non-steroidal anti-inflammatory drug (NSAID), in solid oral dosage forms.

Optimizing Drug Delivery

The researchers investigated the potential of [Kollidon K30 and hydroxypropylmethylcellulose (HPMC)] as polymers for the matrix of prolonged-release ketoprofen tablets. They found that formulations containing HPMC and calcium hydrogen phosphate dihydrate resulted in the most desirable release profiles. The study also noted that Kollidon K30 accelerated the release of ketoprofen, suggesting a potential for fine-tuning release profiles by adjusting the polymer composition.

The Benefits of Prolonged Release

This research demonstrates the potential of [prolonged-release dosage forms] to improve the efficacy and safety of NSAID therapy. By providing sustained drug delivery, these formulations can reduce the frequency of drug administration, potentially leading to better patient compliance and fewer side effects. This study underscores the importance of exploring innovative approaches to drug delivery that enhance patient care.

Dr.Camel's Conclusion

As a researcher who has journeyed through the vast desert of pharmaceutical science, I find this study to be a valuable oasis of knowledge. It reminds me that the development of innovative drug delivery systems is crucial for improving patient outcomes and enhancing the quality of medication therapy. This research inspires me to continue exploring new avenues for drug delivery that optimize therapeutic benefits and minimize potential side effects.

Date :
  1. Date Completed 2017-07-07
  2. Date Revised 2018-10-23
Further Info :

Pubmed ID

28397455

DOI: Digital Object Identifier

10.17219/pim/69296

Related Literature

Article Analysis
・Side Effects of ketoprofen
SNS
PICO Info
in preparation
Languages

Polish

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.