Paper Details

  1. Home
  2. Paper Details

The stimulatory effects of secobarbital and pregnanolone on the GABAA receptor can be blocked selectively.

Author: KirknessE F, TurnerA J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Secobarbital and pregnanolone, both stimulators of GABA receptor binding, showed distinct sensitivities to blockade by phenobarbital, avermectin B1a, and picrotoxinin, suggesting separate interaction sites.
Paper Details　
Original Abstract of the Article :
The stimulatory effects of secobarbital and pregnanolone on GABA receptor binding could be distinguished by their sensitivity to blockade by phenobarbital, avermectin B1a and picrotoxinin. Phenobarbital (1 mM) and avermectin (10(-9)-10(-6) M) inhibited the stimulation of [3H]muscimol binding to pig ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0014-2999(88)90024-6

データ提供：米国国立医学図書館（NLM）

Distinct Mechanisms of Action for Secobarbital and Pregnanolone on GABA Receptors

The GABA receptor, a key player in the intricate network of neurotransmission, is a fascinating subject of research. This study delves into the mechanisms by which secobarbital and pregnanolone, two distinct classes of modulators, interact with the GABA receptor. The researchers used [research method] to investigate the effects of these compounds on [receptor binding]. They found that secobarbital and pregnanolone stimulate GABA receptor binding but through different mechanisms, which are distinct in their sensitivity to blockade by specific inhibitors. This finding provides valuable insights into the complex interaction between these modulators and the GABA receptor.

Distinct Mechanisms of Action: Implications for Drug Development

The research highlights the distinct mechanisms of action of secobarbital and pregnanolone on the GABA receptor. This finding has significant implications for the development of new drugs that target this receptor. Understanding these distinct mechanisms could lead to the development of more targeted and effective drugs for treating conditions associated with GABA receptor dysfunction.

The GABA Receptor: A Complex and Intriguing Target

The GABA receptor is a complex and intriguing target for drug development. Understanding the diverse mechanisms by which various compounds interact with this receptor is crucial for developing new and effective therapies for a wide range of neurological disorders.

Dr.Camel's Conclusion

This research sheds light on the complex interplay between different modulators and the GABA receptor. Understanding these distinct mechanisms of action is essential for developing targeted and effective treatments for neurological conditions. This research provides a valuable contribution to the ongoing quest for new and effective therapies for the vast desert of neurological disorders.

Date :
  1. Date Completed 1988-10-18
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

2843385

DOI: Digital Object Identifier

10.1016/0014-2999(88)90024-6

Related Literature

Article Analysis
・Effects of secobarbital
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.