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Clinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen.

Author: CawsMaxine, DangHa Thi Minh, DayJeremy, DoThu Dang Anh, HeemskerkA Dorothee, LeThao Thi Phuong, NguyenBang Duc, NguyenLan Huu, NguyenMai Thi Hoang, NguyenThuong Thuy Thuong, ThwaitesGuy E, Vinh NguyenChau Van, WolbersMarcel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Early intensified treatment improved survival in patients with isoniazid-resistant tuberculous meningitis (TBM). Targeted regimens for drug-resistant TBM should be further explored.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Drug-resistant tuberculous meningitis (TBM) is difficult to diagnose and treat. Mortality is high and optimal treatment is unknown. We compared clinical outcomes of drug-resistant and -susceptible TBM treated with either standard or intensified antituberculosis treatment. METHODS: We an...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5850451/

データ提供：米国国立医学図書館（NLM）

Drug-Resistant Tuberculosis Meningitis: Navigating a Treacherous Desert

This research delves into the challenging world of drug-resistant tuberculosis meningitis (TBM), a serious infection of the brain and spinal cord that is difficult to treat. The authors investigated the effectiveness of an intensified antituberculosis regimen in patients with drug-resistant TBM.

Intensified Treatment: A Beacon of Hope in the Desert

The study found that an intensified regimen, which included higher doses of rifampicin and levofloxacin, significantly improved survival in patients with isoniazid-resistant TBM. This is like finding a source of water in a desolate desert, offering a lifeline to those in dire need.

Drug-Resistant TBM: A Desert of Challenges

The study emphasizes the importance of early diagnosis and treatment for drug-resistant TBM. It's like navigating a treacherous desert – every moment counts.

Dr.Camel's Conclusion

This research highlights the potential of intensified treatment regimens for drug-resistant TBM. It's like a ray of hope in the vast desert of tuberculosis research. This study emphasizes the importance of tailored treatment approaches and early intervention for patients with this challenging condition.
Date :
  1. Date Completed 2018-06-05
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28472255

DOI: Digital Object Identifier

PMC5850451

SNS
PICO Info
in preparation
Languages

English

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