Meclofenamate blocks the pulmonary arterial vasopressor effects of leukotriene B4 in awake sheep.

Author: LeffertsP L, MillerR F, PurvisA W, SnapperJ R

Paper Details 
Original Abstract of the Article :
This study examined the hemodynamic effects of leukotriene B4 (LTB4) in chronically instrumented awake sheep, and the role of cyclooxygenase products in the sheep's response to LTB4. LTB4 (25 micrograms) was given as a bolus into the pulmonary artery. Six sheep were studied with LTB4, both before an...See full text at original site
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引用元:
https://doi.org/10.1016/0090-6980(88)90006-8

データ提供:米国国立医学図書館(NLM)

Meclofenamate and Leukotriene B4 in Pulmonary Vasoconstriction: A Camel's Perspective

The [pulmonary circulation] is a complex network of vessels, much like a labyrinthine desert. This research, like a camel caravan seeking to [understand the secrets of the desert], explored the role of [leukotriene B4] in [pulmonary vasoconstriction] and the effect of [meclofenamate] on this process. The researchers found that [meclofenamate] effectively [blocked the vasoconstrictive effects of leukotriene B4], potentially offering a way to [manage pulmonary hypertension].

Unlocking the Secrets of the Pulmonary Desert

This study is like a camel caravan discovering a hidden oasis in the [desert of pulmonary hypertension]. The findings suggest that [meclofenamate] could play a role in [managing pulmonary vasoconstriction] and potentially [improving lung function] in patients with [pulmonary hypertension].

Navigating the Pulmonary Desert

This research, like a camel caravan navigating a vast and complex desert, emphasizes the importance of [further research] to fully understand the role of [leukotriene B4] in [pulmonary vasoconstriction] and to develop [more effective treatments] for [pulmonary hypertension].

Dr. Camel's Conclusion

This study is like a camel caravan discovering a new path through the [desert of pulmonary circulation]. By understanding the interactions between [leukotriene B4] and [meclofenamate], we can potentially find new ways to [manage pulmonary hypertension] and improve the well-being of those affected by this challenging condition.

Date :
  1. Date Completed 1989-04-28
  2. Date Revised 2019-08-24
Further Info :

Pubmed ID

2853421

DOI: Digital Object Identifier

10.1016/0090-6980(88)90006-8

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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