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Riluzole exerts distinct antitumor effects from a metabotropic glutamate receptor 1-specific inhibitor on breast cancer cells.

Author: ChenSuzie, DhamiJatinder, DolfiSonia C, GanesanShridar, HirshfieldKim M, KareddulaAparna, MackayGillian, MedinaDaniel J, ParatalaBhavna, RoseAshley, VazquezAlexei

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored the anti-cancer effects of riluzole, a glutamate release inhibitor, in a panel of breast cancer cell lines, comparing it to a metabotropic glutamate receptor 1-specific inhibitor. Riluzole inhibited breast cancer cell proliferation, inducing mitotic arrest independently of oxidative stress and altering cellular metabolism. While BAY 36-7620 also inhibited proliferation, it had a more pronounced effect on DNA damage and no effect on mitosis.
Paper Details　
Original Abstract of the Article :
Recent evidence suggests that glutamate signaling plays an important role in cancer. Riluzole is a glutamate release inhibitor and FDA-approved drug for the treatment of amyotrophic lateral sclerosis. It has been investigated as an inhibitor of cancer cell growth and tumorigenesis with the intention...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546507/

データ提供：米国国立医学図書館（NLM）

Riluzole: A Multifaceted Weapon in the Fight Against Breast Cancer

Glutamate signaling plays a crucial role in various cellular processes, including cancer. Riluzole, an FDA-approved drug for amyotrophic lateral sclerosis, has shown promise in inhibiting cancer cell growth. This research investigates the anti-cancer effects of riluzole in breast cancer cells, exploring its potential as a repurposed drug for treating breast cancer. The study found that riluzole exhibited distinct anti-tumor effects compared to a specific inhibitor of metabotropic glutamate receptor 1, suggesting a broader mechanism of action.

Riluzole: Beyond Glutamate Inhibition

The study suggests that riluzole's anti-cancer effects may extend beyond its known glutamate release inhibition. The researchers found distinct functional effects of riluzole compared to a specific metabotropic glutamate receptor 1 inhibitor, implying a broader spectrum of activity. It's like discovering a hidden oasis in the desert of cancer treatment, offering new pathways to combat breast cancer cells.

Breast Cancer Treatment: A Multifaceted Approach

The study highlights the potential of riluzole as a repurposed drug for treating breast cancer. It underscores the importance of exploring new therapeutic strategies and understanding the diverse mechanisms of action of existing drugs. It's a reminder that even in the vast desert of cancer research, new discoveries can emerge, offering hope for a brighter future for patients.

Dr.Camel's Conclusion

This study offers exciting insights into the anti-cancer potential of riluzole. It suggests that riluzole may exert broader anti-tumor effects beyond its known glutamate inhibition, highlighting its potential as a repurposed drug for treating breast cancer. It's a testament to the ongoing efforts to discover new and innovative therapies for cancer, providing hope for a more effective and personalized approach to treatment.
Date :
  1. Date Completed 2018-03-29
  2. Date Revised 2023-11-13
Further Info :

Pubmed ID

28591718

DOI: Digital Object Identifier

PMC5546507

Related Literature

Article Analysis
・Effects of riluzole
SNS
PICO Info
in preparation
Languages

English

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