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Cysteinyl Leukotriene Receptor Antagonists Inhibit Migration, Invasion, and Expression of MMP-2/9 in Human Glioblastoma.

Author: ChaithirayanonKulathida, PiromkraipakPannaree, PowerChristopher, SangpairojKant, SupavilaiPorntip, TirakotaiWuttipong, UnchernSupeenun, VivithanapornPornpun

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigates the anti-migratory effects of two leukotriene receptor antagonists (LTRAs), montelukast and zafirlukast, in glioblastoma cells. The findings suggest that LTRAs may inhibit migration and invasion of glioma cells by targeting cysteinyl leukotriene receptor 1 (CysLT1) and reducing the expression and activity of MMP-2 and MMP-9.
Paper Details　
Original Abstract of the Article :
Glioblastoma is one of the most malignant and aggressive types of brain tumors. 5-lipoxygenase and cysteinyl leukotriene receptor 1 (CysLT1) play a role in human carcinogenesis. Leukotriene receptor antagonists (LTRAs), anti-asthmatic drugs with mild side effects, have anti-metastatic activity in ep...See full text at original site
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引用元：
https://doi.org/10.1007/s10571-017-0507-z

データ提供：米国国立医学図書館（NLM）

Combatting Glioblastoma: A New Frontier in Cancer Research

This study, published in [Journal Name], explores the potential of cysteinyl leukotriene receptor antagonists (LTRAs) as a novel therapeutic strategy for treating glioblastoma, an aggressive brain tumor. The researchers meticulously investigate the effects of two LTRAs, montelukast and zafirlukast, on glioblastoma cell migration, invasion, and matrix metalloproteinase (MMP) expression.

Targeting Leukotriene Receptors in Glioblastoma

The study reveals that LTRAs effectively inhibit glioblastoma cell migration and invasion, suggesting that leukotriene receptors play a critical role in the metastatic spread of this deadly cancer. The findings also highlight the potential of LTRAs to block the expression and activity of MMP-2 and MMP-9, key enzymes involved in tumor invasion.

A Glimpse of Hope for Glioblastoma Patients

This research offers a glimmer of hope for patients battling glioblastoma. The findings suggest that LTRAs, currently used for asthma treatment, may hold promise as a novel therapeutic approach for managing this aggressive brain tumor.

Dr. Camel's Conclusion

This study highlights the boundless possibilities of repurposing existing drugs for new therapeutic applications. Like a desert oasis, LTRAs may provide a life-saving solution for glioblastoma patients, offering a promising path toward effective treatment and improved survival.

Date :
  1. Date Completed 2018-08-27
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

28600709

DOI: Digital Object Identifier

10.1007/s10571-017-0507-z

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Article Analysis
・Side Effects of zafirlukast
SNS
PICO Info
in preparation
Languages

English

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