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Evidence for a pharmacokinetic interaction between eslicarbazepine and rosuvastatin: Potential effects on xenobiotic transporters.

Author: BlumDavid, GidalBarry E, GrinnellTodd, KharidiaJahnavi, MintzerScott, SchutzRalph, SchwabMatthias, SunkaraneniSoujanya

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examines the effect of multiple-dose eslicarbazepine acetate (ESL), an antiepileptic drug, on the pharmacokinetic (PK) parameters of a single dose of rosuvastatin, an HMG-CoA reductase inhibitor, in healthy subjects.
Paper Details　
Original Abstract of the Article :
Patients with partial-onset seizures and comorbid cardiovascular disease may concomitantly receive eslicarbazepine acetate (ESL), an antiepileptic drug, and rosuvastatin, an HMG-CoA reductase inhibitor. This study evaluated the effect of multiple-dose ESL on the pharmacokinetic (PK) parameters of a ...See full text at original site
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引用元：
https://doi.org/10.1016/j.eplepsyres.2017.05.005

データ提供：米国国立医学図書館（NLM）

Eslicarbazepine and Rosuvastatin: A Potential Interaction in the Desert of Drug Interactions

The world of drug interactions is a vast and complex desert, filled with hidden dangers and potential pitfalls. This study, like a careful explorer, delved into the interaction between two commonly prescribed medications: eslicarbazepine acetate (ESL), used for seizures, and rosuvastatin, a cholesterol-lowering drug. The researchers wanted to see if taking ESL could affect how the body processed rosuvastatin.

The study, conducted on healthy volunteers, found evidence suggesting a possible interaction between the two drugs. This discovery highlights the need for further research to understand the implications of this potential interaction for patients taking both medications.

A Need for Caution in the Desert

This study underscores the importance of caution when prescribing medications, particularly when dealing with potential interactions. Further research is needed to better understand the implications of this possible interaction between eslicarbazepine and rosuvastatin.

Navigating the Desert of Drug Interactions

This study serves as a reminder that we must navigate the desert of drug interactions with careful consideration. It emphasizes the need for continued research to ensure the safety and efficacy of medications for our patients.

Dr.Camel's Conclusion

This study reminds us that the desert of drug interactions is vast and complex, with hidden dangers lurking beneath the surface. While we strive to navigate this landscape safely, we must remain vigilant, conducting thorough research to ensure the well-being of our patients.

Date :
  1. Date Completed 2018-01-29
  2. Date Revised 2018-02-11
Further Info :

Pubmed ID

28624574

DOI: Digital Object Identifier

10.1016/j.eplepsyres.2017.05.005

Related Literature

Article Analysis
・Effects of eslicarbazepine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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