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Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis.

Author: ChenChun-Li, FangXiao-Ling, LiLin, TongYao, WangYi-Xiao, WangZhao-Yang, ZhouYa-Li

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This study discussed the use of anti-angiogenesis treatments, particularly anti-vascular endothelial growth factor (VEGF) drugs like ranibizumab and bevacizumab, for exudative age-related macular degeneration (AMD), acknowledging the variability in treatment response.
Paper Details　
Original Abstract of the Article :
Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) drugs with ranibizumab and bevacizumab are current standard treatments. However, the outcome ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5480205/

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Anti-VEGF Treatment for Exudative AMD

The world of ophthalmology is constantly evolving, and this study delves into the complexities of treating exudative age-related macular degeneration (AMD) with anti-vascular endothelial growth factor (VEGF) therapies. The authors investigate the association between a specific polymorphism in the HTRA1 gene and the response to anti-VEGF treatment, seeking to identify factors that contribute to variable treatment outcomes. They perform a meta-analysis of existing studies to assess the potential influence of this genetic variation on treatment response. The study provides valuable insights into the genetic factors that may influence the efficacy of anti-VEGF treatments for exudative AMD, paving the way for personalized therapies and improved treatment outcomes.

A Genetic Compass for Anti-VEGF Treatment

This meta-analysis sheds light on the potential role of genetics in influencing the response to anti-VEGF treatment for exudative AMD. It suggests that the HTRA1 gene polymorphism rs11200638 may be a valuable marker for predicting treatment response. The findings emphasize the importance of considering genetic factors in tailoring treatment strategies for individual patients, potentially leading to more effective and personalized approaches to managing this complex condition.

A New Horizon in AMD Treatment

This study offers a glimmer of hope in the desert of AMD research. It highlights the potential for genetic testing to guide treatment decisions for exudative AMD, potentially leading to more effective and personalized therapies. The research underscores the importance of exploring genetic factors in understanding the variability of treatment responses and tailoring treatments to individual patients.

Dr.Camel's Conclusion

This meta-analysis provides valuable insights into the potential role of genetics in influencing the response to anti-VEGF treatment for exudative AMD. It suggests that genetic testing may be a valuable tool for predicting treatment response and tailoring therapies to individual patients.

Date :
  1. Date Completed 2017-10-04
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

28637435

DOI: Digital Object Identifier

PMC5480205

Related Literature

Article Analysis
・Effective treatment of macular degeneration
SNS
PICO Info
in preparation
Languages

English

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