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Ceftriaxone reduces alcohol intake in outbred rats while upregulating xCT in the nucleus accumbens core.
Author: FrankowskiJan C, KnackstedtLori A, PerisJoanna, StennettBethany A
Original Abstract of the Article :
Alcohol addiction is a chronic disease characterized by an inability to regulate drinking. A critical brain region involved in alcohol consumption is the nucleus accumbens (NA). Glutamate transmission in this region regulates alcohol consumption and relapse to alcohol-seeking. Across multiple alcoho...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/j.pbb.2017.07.001
データ提供:米国国立医学図書館(NLM)
Ceftriaxone: Could This Antibiotic Help Curb Alcohol Consumption?
Alcohol addiction is a complex and challenging condition, and finding effective treatments is a top priority for researchers. This study investigates the potential of ceftriaxone, an antibiotic, to reduce alcohol consumption in rats.
The study used an intermittent access to alcohol paradigm to induce alcohol consumption in outbred rats. The researchers found that ceftriaxone treatment significantly reduced alcohol consumption during the treatment period and even after treatment ended. This effect was linked to an increase in the expression of xCT, a protein involved in regulating glutamate levels in the nucleus accumbens, a brain region known to play a key role in alcohol consumption.
A Potential New Weapon in the Fight Against Alcohol Addiction
These findings offer a glimmer of hope in the battle against alcohol addiction. While more research is needed, the study suggests that ceftriaxone could potentially be a valuable tool for reducing alcohol consumption.
Ceftriaxone: A Potential Oasis in the Desert of Alcohol Addiction
This research is like finding a hidden oasis in the vast desert of alcohol addiction. While it's too early to celebrate, the potential of ceftriaxone as a treatment for alcohol addiction is exciting.
Dr. Camel's Conclusion
This study is like a camel caravan discovering a new trade route – it points to a potential new path for addressing alcohol addiction. While further research is needed, the findings offer a promising glimpse into a potentially effective treatment.
Date :
- Date Completed 2018-05-21
- Date Revised 2018-09-17
Further Info :
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