A single center, open label study of intradermal administration of an inactivated purified chick embryo cell culture rabies virus vaccine in adults.

Author: OsinubiModupe O V, RecuencoSergio, RupprechtCharles E, WarnockEli

Paper Details 
Original Abstract of the Article :
In the USA, rabies vaccines (RVs) are licensed for intramuscular (IM) use only, although RVs are licensed for use by the intradermal (ID) route in many other countries. Recent limitations in supplies of RV in the USA reopened discussions on the more efficient use of available biologics, including ut...See full text at original site
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引用元:
https://doi.org/10.1016/j.vaccine.2017.06.083

データ提供:米国国立医学図書館(NLM)

Intradermal Administration of an Inactivated Purified Chick Embryo Cell Culture Rabies Virus Vaccine

The desert of rabies prevention is a landscape where every precaution counts. This study investigates the safety and immunogenicity of an inactivated purified chick embryo cell (PCEC) rabies virus vaccine administered via the intradermal (ID) route in adults.

The researchers conducted an open-label study comparing the immunogenicity and adverse effects of ID and intramuscular (IM) vaccination. They evaluated antibody titers and monitored for adverse events in 130 adult volunteers.

The study demonstrated that ID administration of the PCEC rabies vaccine was safe and immunogenic, with comparable antibody responses to IM vaccination. The ID route allowed for a more efficient use of vaccine, offering potential advantages in terms of resource utilization and minimizing waste.

A New Avenue for Rabies Vaccination

This research offers a promising alternative approach to rabies vaccination, with the potential to improve vaccine efficiency and resource utilization. The findings suggest that ID administration could be a viable and effective option for rabies pre-exposure prophylaxis and booster vaccinations.

Navigating the Desert of Rabies Prevention

This research highlights the importance of continuous innovation and exploration in the field of rabies prevention. Finding more efficient and effective vaccination strategies is crucial for protecting individuals and communities from this potentially fatal disease. It's a reminder that even in the face of challenging conditions, we can find new solutions and continue to make progress in the fight against disease.

Dr.Camel's Conclusion

This study shows that the desert of rabies prevention is full of potential for new discoveries and advancements. By exploring different routes of administration and optimizing vaccine delivery, we can strengthen our defenses against this deadly virus and protect more people from its devastating effects.

Date :
  1. Date Completed 2018-03-19
  2. Date Revised 2018-04-02
Further Info :

Pubmed ID

28688782

DOI: Digital Object Identifier

10.1016/j.vaccine.2017.06.083

Related Literature

SNS
PICO Info
in preparation
Languages

English

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