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Delayed Treatment Response in a Neonate with Multisystem Langerhans Cell Histiocytosis Case report and review of literature.

Author: MandalAnirban, MishraSataroopa, PatelAnkita, SinghAmitabh, SinghLavleen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

A two-month-old boy was diagnosed with multisystem Langerhans cell histiocytosis (LCH), a rare disease, after experiencing pulmonary symptoms and a worsening rash. The diagnosis was delayed due to non-specific symptoms. He received combined chemotherapy with a delayed but successful response and no major side effects.
Paper Details　
Original Abstract of the Article :
Langerhans cell histiocytosis (LCH) is a rare proliferative disorder of the Langerhans cells, which are part of the mononuclear phagocytic system. The disorder varies in terms of the extent of the disease, its natural course and patient outcomes. While skin rashes are a common presentation of neonat...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5488827/

データ提供：米国国立医学図書館（NLM）

Langerhans Cell Histiocytosis: A Rare and Often Overlooked Condition

The human body is a complex and mysterious desert, and sometimes rare conditions like Langerhans cell histiocytosis (LCH) can emerge like hidden oases. This case report delves into the diagnosis and treatment of a two-month-old male neonate who presented with multisystem LCH, highlighting the challenges associated with this rare disorder. The authors highlight the importance of timely diagnosis and the need for increased awareness of LCH among healthcare professionals.

Delayed Diagnosis: A Common Challenge in Langerhans Cell Histiocytosis

The case report demonstrates the challenges associated with diagnosing LCH, particularly in neonates. The non-specific presentation can lead to delays in diagnosis, potentially impacting treatment outcomes. The authors emphasize the importance of early diagnosis and prompt intervention to ensure optimal management of this complex condition.

Understanding Langerhans Cell Histiocytosis: A Journey of Awareness

The case report serves as a reminder of the importance of continued research and education regarding rare diseases like LCH. Increased awareness among healthcare professionals can lead to earlier diagnosis, improving treatment outcomes and potentially reducing the long-term impact of this condition. For families facing this challenge, knowledge and support are crucial for navigating this complex and often misunderstood condition.

Dr. Camel's Conclusion

LCH is a rare and often overlooked condition, but it is crucial for healthcare professionals to be aware of its potential manifestations. This case report serves as a reminder of the importance of vigilance and early diagnosis in treating rare diseases. Like a hidden oasis in a vast desert, understanding and treating LCH requires a dedicated and knowledgeable approach to ensure the well-being of those affected by this rare disorder.

Date :
  1. Date Completed 2018-12-21
  2. Date Revised 2018-12-21
Further Info :

Pubmed ID

28690898

DOI: Digital Object Identifier

PMC5488827

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English

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