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Effects from a 90-day inhalation toxicity study with cerium oxide and barium sulfate nanoparticles in rats.

Author: CreutzenbergOtto, DasenbrockClemens, ErnstHeinrich, KockHeiko, PohlmannGerhard, SchaudienDirk, SchwotzerDaniela

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the pulmonary effects of CeO<sub>2</sub>NM-212 and BaSO<sub>4</sub>NM-220 nanoparticles in a 90-day exposure setup in mice. The study found that both nanoparticles accumulated in the lungs, but BaSO<sub>4</sub>NM-220 nanoparticles accumulated at higher levels. Both nanoparticles induced inflammatory responses in the lungs, but no significant overload-related effects were observed.
Paper Details　
Original Abstract of the Article :
Label="BACKGROUND">Nanomaterials like cerium oxide and barium sulfate are frequently processed in industrial and consumer products and exposure of humans and other organisms is likely. Generally less information is given on health effects and toxicity, especially regarding long-term exposure to low ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508701/

データ提供：米国国立医学図書館（NLM）

Nanoparticle Inhalation: Exploring the Long-Term Effects of Cerium Oxide and Barium Sulfate

The increasing use of nanomaterials in various industrial and consumer products has raised concerns about their potential health effects, particularly following inhalation exposure. This study delves into the long-term pulmonary effects of inhaling cerium oxide and barium sulfate nanoparticles in rats, examining the impact of chronic exposure over a 90-day period. The researchers investigated the effects of different nanoparticle doses on various parameters, including histopathology, bronchoalveolar lavage, and immunohistochemistry. The study aimed to provide insights into the potential mechanisms of action and the relationship between particle deposition, clearance rates, and overload-related effects.

Nanoparticle Inhalation: A Complex Relationship with Pulmonary Health

This study provides valuable insights into the complex relationship between nanoparticle inhalation and pulmonary health. The researchers' meticulous investigation of long-term exposure effects in rats, combined with their analysis of particle deposition and clearance rates, offers a better understanding of the potential risks associated with inhaling these nanomaterials.

Navigating the Nanotechnology Landscape: A Call for Caution

The study's findings underscore the importance of further research into the potential health effects of nanoparticle inhalation. The authors' emphasis on the need for caution and ongoing monitoring is crucial, as we navigate the rapidly evolving landscape of nanotechnology.

Dr.Camel's Conclusion

Just as a desert wind can carry fine grains of sand, inhalation can expose our lungs to nanoparticles. This study explores the long-term effects of inhaling cerium oxide and barium sulfate nanoparticles, reminding us of the need for ongoing research and caution. As we embrace the innovations of nanotechnology, we must proceed with awareness and vigilance, ensuring the safety of our health and environment.

Date :
  1. Date Completed 2018-04-25
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28701164

DOI: Digital Object Identifier

PMC5508701

Related Literature

Article Analysis
・Effects of barium sulfate
SNS
PICO Info
in preparation
Languages

English

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