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Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation.
Author: ChakravarthiSrikumar, ChellianJestin, DavidSheba R, MunChung Yee, RajabalayaRajan
Original Abstract of the Article :
The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength,...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://pubmed.ncbi.nlm.nih.gov/28858835
データ提供:米国国立医学図書館(NLM)
Transdermal Delivery of Tolterodine Tartrate for Overactive Bladder
This study explores the potential of transdermal delivery of tolterodine tartrate (TT) for treating overactive bladder (OAB). The researchers developed and characterized transdermal TT patches using various polymers and plasticizers. They evaluated the patches' in vitro release, permeation, and effectiveness in animal models. The study found that the transdermal TT patches showed satisfactory release profiles and mechanical properties. Animal studies indicated that the patches reduced the incidence of side effects. However, further studies of longer duration are needed to determine the effectiveness of transdermal TT patches in treating OAB.
Transdermal Tolterodine Tartrate: A Potential Alternative for OAB Treatment
The study suggests that transdermal delivery of TT could be a viable alternative for treating OAB. The potential for reduced side effects compared to oral administration makes this approach particularly attractive. Further research is needed to confirm the effectiveness of transdermal TT patches and to optimize their formulation and delivery.
Exploring New Treatment Options for Overactive Bladder
The study highlights the ongoing search for effective and well-tolerated treatments for OAB. The development of transdermal TT patches represents a promising new avenue for addressing this common condition. Further research will be crucial to determine the long-term efficacy and safety of this approach.
Dr.Camel's Conclusion
Just as a camel adapts to its harsh desert environment, researchers are seeking innovative ways to manage overactive bladder. This study explores the potential of transdermal delivery of tolterodine tartrate, offering a promising approach that could provide a more convenient and potentially safer alternative to oral medications. It's a reminder that even in the face of challenging medical conditions, the pursuit of better treatments continues, driven by the desire to improve patient well-being.
Date :
- Date Completed 2017-10-30
- Date Revised 2018-12-02
Further Info :
Pubmed ID
DOI: Digital Object Identifier
Related Literature
English
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