Effects of the combined administration of entecavir and adefovir dipivoxil to improve hepatic fibrosis in hepatitis B patients with interferon resistance.

Author: ChangShuzhen, ChenBinhe, QiuLing, ShenFei, SunYuqiu, WuKeqin, YuLijun

Paper Details 
Original Abstract of the Article :
BACKGROUND: To observe the effect of the combined administration of entecavir and adefovir dipivoxil to improve hepatic fibrosis in hepatitis B patients with interferon resistance. METHODS: This study comprised 90 hepatitis B patients with hepatic fibrosis and interferon (IFN) resistance who were a...See full text at original site
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引用元:
https://doi.org/10.23736/S0026-4806.17.05222-3

データ提供:米国国立医学図書館(NLM)

Combating Hepatitis B: A Combined Approach to Improve Liver Fibrosis

Hepatitis B, like a desert storm, can leave a trail of devastation in its wake, affecting the liver and its ability to function. This research explores the combined administration of entecavir and adefovir dipivoxil as a treatment strategy for hepatitis B patients who have shown resistance to interferon therapy. The study investigated the effects of this combined treatment approach on liver function and fibrosis in 90 patients with hepatic fibrosis and interferon resistance.

The findings demonstrate that the combined administration of entecavir and adefovir dipivoxil significantly improved liver function, hepatic fibrosis, and Model for End-Stage Liver Disease (MELD) scores in patients with interferon resistance. This suggests that this combination therapy could offer a promising treatment option for individuals with hepatitis B who have not responded well to standard interferon therapy.

A New Hope for Hepatitis B Treatment

This study provides encouraging evidence for the effectiveness of combining entecavir and adefovir dipivoxil in treating hepatitis B patients with interferon resistance. The observed improvements in liver function and fibrosis highlight the potential benefits of this combination therapy and underscore the need to promote its application in clinical practice.

Managing Hepatitis B: A Multifaceted Approach

The study emphasizes the importance of a multifaceted approach to managing hepatitis B, with individualized treatment strategies tailored to the specific needs of each patient. Further research into the long-term effects of this combination therapy is crucial to ensure its safety and efficacy over time.

Dr. Camel's Conclusion

Just as a desert traveler seeks a reliable source of water to survive, hepatitis B patients require effective treatment strategies to combat the disease. This research provides a promising path toward more effective treatment options, offering a glimmer of hope in the fight against this challenging condition.

Date :
  1. Date Completed 2017-11-20
  2. Date Revised 2017-11-28
Further Info :

Pubmed ID

28889724

DOI: Digital Object Identifier

10.23736/S0026-4806.17.05222-3

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English

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