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Solid lipid nanoparticles for the controlled delivery of poorly water soluble non-steroidal anti-inflammatory drugs.

Author: GargNeha, KumarRaj, SinghAshutosh, SirilPrem Felix

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Ibuprofen is a common pain reliever that can be difficult to absorb into the body. This study developed a new way to deliver ibuprofen that may improve absorption and reduce side effects.
Paper Details　
Original Abstract of the Article :
Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (IBP) are among the most prescribed drugs across the globe. However, most NSAIDs are insoluble in water leading them to have poor bioavailability and erratic absorption. Moreover, NSAIDs such as IBP and ketoprofen (KP) have to be admin...See full text at original site
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引用元：
https://doi.org/10.1016/j.ultsonch.2017.08.018

データ提供：米国国立医学図書館（NLM）

Harnessing the Power of Nanoparticles for Drug Delivery

Non-steroidal anti-inflammatory drugs (NSAIDs) are like dependable camels in the world of medicine, carrying a powerful therapeutic payload. However, their poor water solubility can hinder their effectiveness. This study investigates the potential of solid lipid nanoparticles (SLNs) as a delivery system for poorly water-soluble NSAIDs. The researchers crafted SLNs that effectively encapsulated NSAIDs like ibuprofen (IBP) and ketoprofen (KP), offering a promising solution to the challenges posed by their limited solubility.

A Novel Approach to Optimizing Drug Delivery

This research demonstrates the effectiveness of SLNs in encapsulating and delivering NSAIDs. The study's optimized formulation resulted in SLNs with small particle size and high drug loading, leading to sustained drug release over an extended period. These findings point towards a promising approach for improving the bioavailability and efficacy of NSAIDs.

A New Path to Better NSAID Delivery

The use of SLNs for delivering NSAIDs could significantly improve their effectiveness by enhancing their solubility and bioavailability. This approach might lead to more convenient dosing schedules, reduced side effects, and better therapeutic outcomes for patients.

Dr.Camel's Conclusion

This research showcases the innovative potential of nanotechnology in drug delivery. SLNs offer a promising solution to the challenge of delivering poorly soluble NSAIDs, paving the way for more effective and convenient treatment options. This discovery is like finding a hidden spring in the desert, providing a source of potential for improving patient outcomes and enhancing the therapeutic landscape.

Date :
  1. Date Completed 2018-07-23
  2. Date Revised 2018-07-23
Further Info :

Pubmed ID

28946474

DOI: Digital Object Identifier

10.1016/j.ultsonch.2017.08.018

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Languages

English

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