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The Nottingham study of neurotic disorder: comparison of drug and psychological treatments.

Author: BarczakP, BrothwellJ, DarlingC, FergusonB, GregoryS, JohnsonA L, KingdonD, MurphyS, SeivewrightN, TyrerP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the effectiveness of different treatments for generalized anxiety disorder, panic disorder, and dysthymic disorder in 210 patients. Treatments included diazepam, dothiepin, placebo, cognitive-behavioral therapy, and a self-help program. All treatments lasted for six weeks, followed by a four-week withdrawal period. The study found no significant differences in treatment effectiveness between the different diagnoses, but diazepam was less effective than dothiepin, cognitive-behavioral therapy, or the self-help program. These three treatments were equally effective. Placebo patients were more likely to require additional medications, while those taking dothiepin or receiving cognitive-behavioral therapy required the fewest additional medications.
Paper Details　
Original Abstract of the Article :
210 psychiatric outpatients with generalised anxiety disorder (71), or panic disorder (74), or dysthymic disorder (65) diagnosed by an interview schedule for DSM-III were allocated by constrained randomisation to one of five treatments: diazepam (28), dothiepin (28), placebo (28), cognitive and beha...See full text at original site
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引用元：
https://doi.org/10.1016/s0140-6736(88)92535-4

データ提供：米国国立医学図書館（NLM）

Comparing Drug and Psychological Treatments for Neurotic Disorders

This study compared the effectiveness of different treatment approaches for neurotic disorders, including generalized anxiety disorder, panic disorder, and dysthymic disorder. The study assigned patients to one of five treatment groups: diazepam, dothiepin, placebo, cognitive and behavior therapy, and a self-help program.

Cognitive and Behavior Therapy Shows Promise for Neurotic Disorders

The study found that dothiepin, cognitive and behavior therapy, and self-help were all more effective than diazepam and placebo in reducing symptoms of neurotic disorders. Cognitive and behavior therapy and self-help were found to be equally effective in improving patient outcomes. These findings suggest that psychological interventions may be a valuable alternative or complement to medication in the treatment of neurotic disorders.

Empowering Patients with Psychological Therapies

This research highlights the importance of considering psychological therapies, such as cognitive and behavior therapy, as effective treatment options for neurotic disorders. These therapies empower patients by teaching them coping strategies and helping them develop more adaptive ways of thinking and behaving.

Dr. Camel's Conclusion

This study provides valuable insights into the effectiveness of different treatment approaches for neurotic disorders. It demonstrates the potential of psychological therapies, such as cognitive and behavior therapy, as effective and potentially more sustainable treatment options compared to medications. It's important for healthcare professionals to consider these therapies as valuable tools in their treatment arsenal.
Date :
  1. Date Completed 1988-08-25
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

2899234

DOI: Digital Object Identifier

10.1016/s0140-6736(88)92535-4

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PICO Info
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Languages

English

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