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Hypothermic oxygenated machine perfusion (HOPE) for orthotopic liver transplantation of human liver allografts from extended criteria donors (ECD) in donation after brain death (DBD): a prospective multicentre randomised controlled trial (HOPE ECD-DBD).

Author: AmygdalosIakovos, BednarschJan, BoteaFlorin, CramerThorsten, CziganyZoltan, DejongCornelis H C, FroněkJiří, HeinMarc, KochAlexander, KoekGer H, KroyDaniela, LurjeGeorg, NeumannUlf Peter, PopescuIrinel, RogiersXavier, SchöningWenzel, TackeFrank, TolbaRene H, TrautweinChristian, UlmerTom Florian

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Orthotopic liver transplantation (OLT) is the standard treatment for end-stage liver disease, and using extended criteria donor (ECD) liver allografts may improve access to donor organs. Hypothermic oxygenated machine perfusion (HOPE) shows promise for reconditioning poor quality ECD liver allografts.
Paper Details　
Original Abstract of the Article :
Orthotopic liver transplantation (OLT) has emerged as the mainstay of treatment for end-stage liver disease. In an attempt to improve the availability of donor allografts and reduce waiting list mortality, graft acceptance criteria were extended increasingly over the decades. The use of extended cri...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652559/

データ提供：米国国立医学図書館（NLM）

HOPE ECD-DBD: A promising approach for liver transplantation?

The field of [liver transplantation] faces a constant challenge in finding suitable donor organs. This study delves into the world of [extended criteria donor (ECD) allografts] which, like [a camel finding a rare oasis in the desert], are a valuable resource but come with their own set of challenges. The study investigates the use of [Hypothermic oxygenated machine perfusion (HOPE)] as a way to recondition these ECD organs, potentially making them suitable for transplantation. The authors conducted a [prospective multicentre randomised controlled trial] and found that HOPE might be a viable option for improving the success of liver transplantation from ECD donors.

HOPE ECD-DBD: A potential game-changer in liver transplantation?

The findings suggest that HOPE could be a valuable tool for increasing the pool of available donor livers. This could translate to [fewer patients on waiting lists] and [a better chance of survival for those in need of a transplant]. This exciting discovery could be [a beacon of hope] for those struggling with end-stage liver disease.

HOPE ECD-DBD: A ray of hope for liver transplant recipients?

This study is a step towards [a future where ECD livers can be used more effectively], but it's still early days. However, the potential benefits are significant, especially for those facing [a long wait for a suitable liver]. The study highlights the importance of [continued research and development in this field] to ensure that the benefits of HOPE are fully realized.

Dr.Camel's Conclusion

This study is a fascinating journey through the world of [liver transplantation]. The authors have unearthed a potential game-changer in [HOPE], which could be a vital tool for [enhancing the supply of donor organs] and [improving patient outcomes]. The findings offer a glimmer of hope for [those seeking a second chance at life through organ transplantation]. It's a reminder that even in the vast and often challenging landscape of [medical research], there are always new discoveries to be made that can improve the health and well-being of those in need.

Date :
  1. Date Completed 2018-06-11
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

29018070

DOI: Digital Object Identifier

PMC5652559

Related Literature

Article Analysis
・Effective treatment of liver transplantation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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