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The possible role of dopamine autoreceptors in neuroleptic atypicality.

Author: JavittD C, OplerL A, WeinsteinS L

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Molindone, a novel neuroleptic, was found to preferentially inhibit dopamine autoreceptors, which may explain its distinct clinical effects, including reduced risk of tardive dyskinesia and improved negative schizophrenic symptoms.
Paper Details　
Original Abstract of the Article :
Different brain pathways have been shown to subserve the therapeutic effects of neuroleptics and their extrapyramidal side effects. Agents which can discriminate between these pathways, therefore, might be able to produce 'atypical' clinical effects. Molindone, a novel neuroleptic of the indoleamine...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2902622

データ提供：米国国立医学図書館（NLM）

Dopamine Autoreceptors: Navigating the Desert of Atypical Neuroleptics

Neuroleptic medications, used to treat psychiatric disorders, often come with undesirable side effects. This study explores the potential role of dopamine autoreceptors in the development of atypical neuroleptic effects. The researchers investigated the unique properties of molindone, a novel neuroleptic that preferentially inhibits dopamine autoreceptors, and its implications for clinical efficacy and side effect profile.

Molindone: A Potential Oasis in the Desert of Neuroleptic Treatment

The study suggests that molindone's ability to preferentially block dopamine autoreceptors might contribute to its atypical clinical profile, potentially reducing the risk of tardive dyskinesia and improving the treatment of negative schizophrenic symptoms. The authors propose that this selective action on dopamine autoreceptors may explain the distinctive clinical effects observed with molindone compared to traditional neuroleptics.

Navigating the Complexities of Neuroleptic Treatment

This study offers valuable insights into the neurobiological mechanisms underlying atypical neuroleptic effects. It highlights the importance of targeting specific neuronal pathways to optimize treatment outcomes and minimize side effects. Further research is needed to fully elucidate the role of dopamine autoreceptors in mediating the clinical effects of neuroleptics.

Dr. Camel's Conclusion

The treatment of psychiatric disorders can feel like a journey through a vast and challenging desert, with the need to balance therapeutic benefits against potential side effects. This study suggests that selectively targeting dopamine autoreceptors with medications like molindone might offer a more effective and tolerable approach to neuroleptic treatment. As a wise old camel, I always encourage seeking professional guidance and exploring all available treatment options to find the right path through the complexities of mental health.

Date :
  1. Date Completed 1988-11-16
  2. Date Revised 2007-11-14
Further Info :

Pubmed ID

2902622

DOI: Digital Object Identifier

2902622

Related Literature

Article Analysis
・Side Effects of molindone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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