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Time to treatment for rifampicin-resistant tuberculosis: systematic review and meta-analysis.

Author: BoydR, CoxH, FordN, PadgenP

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Time to treatment for RR-TB is extremely variable across studies, and often unnecessarily long. Reduced delays are associated with genotypic testing and ambulatory treatment settings.
Paper Details　
Original Abstract of the Article :
BACKGROUND: To reduce transmission and improve patient outcomes, rapid diagnosis and treatment of rifampicin-resistant tuberculosis (RR-TB) is required. OBJECTIVE: To conduct a systematic review and meta-analysis assessing time to treatment for RR-TB and variability using diagnostic testing methods...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644740/

データ提供：米国国立医学図書館（NLM）

Time to Treatment for Rifampicin-Resistant Tuberculosis: A Systematic Review and Meta-Analysis

Tuberculosis (TB) is a persistent threat, much like a stubborn sand dune. This study investigates the time it takes to initiate treatment for [rifampicin-resistant tuberculosis (RR-TB)], a form of TB resistant to one of the most effective TB drugs. The authors conducted a [systematic review and meta-analysis] of studies reporting time to treatment initiation for RR-TB, exploring the factors that influence this crucial aspect of care.

The study, which included [83 cohorts] representing [13,034 patients], found that time to treatment from specimen collection was significantly longer for patients treated in [hospital-based] settings compared to those treated in [ambulatory] settings. Additionally, the study found that time to treatment was shorter for patients diagnosed using [genotypic susceptibility testing] compared to those diagnosed using [phenotypic testing].

Shortening Time to Treatment for RR-TB

The study’s findings highlight the need to reduce delays in treatment initiation for RR-TB. The authors emphasize the importance of using [genotypic susceptibility testing] and [ambulatory treatment] settings to optimize time to treatment. These strategies could improve patient outcomes and reduce the transmission of RR-TB.

Implications for TB Control and Patient Outcomes

The timely initiation of treatment is crucial for improving patient outcomes and preventing the spread of TB. By implementing strategies that shorten time to treatment, we can make a significant impact on TB control efforts and improve the health of individuals with this challenging disease.

Dr.Camel's Conclusion

This study shines a light on the importance of timely treatment for RR-TB. The findings emphasize the need to streamline the diagnostic and treatment processes to ensure that patients receive the appropriate care as quickly as possible. While TB may seem like an insurmountable challenge, we can effectively combat this disease by implementing strategies that optimize time to treatment.

Date :
  1. Date Completed 2018-06-08
  2. Date Revised 2019-01-16
Further Info :

Pubmed ID

29037299

DOI: Digital Object Identifier

PMC5644740

SNS
PICO Info
in preparation
Languages

English

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