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Verapamil (VER) Enhances the Cytotoxic Effects of Docetaxel and Vinblastine Combined Therapy Against Non-Small Cell Lung Cancer Cell Lines.

Author: DaraeeHadis, JaferianSoleiman, SoleymaninejadMaryam

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study found that combining vinblastine and docetaxel was more effective in killing NSCLC cells than either drug alone, and that verapamil can enhance the efficacy of the combination therapy by reducing drug resistance.
Paper Details　
Original Abstract of the Article :
Lung cancer is one of the foremost tumor-associated cause of death in the world. Most of the patients with NSCLC possesses an advanced disease at diagnosis, and are thus probable subject for systemic therapy. This study aims to evaluate the cytotoxicity of vinblastine and docetaxel combined therapy ...See full text at original site
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引用元：
https://doi.org/10.1055/s-0043-117895

データ提供：米国国立医学図書館（NLM）

Combating Drug Resistance in Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is a formidable foe in the world of oncology. This research explores the potential of combining vinblastine and docetaxel, two chemotherapy drugs, to treat NSCLC. The study aims to assess the cytotoxic effects of this combination therapy, as well as the role of verapamil (VER), a drug known to enhance the effectiveness of certain chemotherapy agents, in potentially overcoming drug resistance. Researchers utilized P-glycoprotein (P-gp) gene and protein expression analysis, along with DAPI staining to evaluate cell apoptosis. The results indicated that the combination therapy was more effective in promoting cell apoptosis compared to each drug used individually. Furthermore, the combination therapy significantly reduced the drug-induced up-regulation of mdr-1, a gene associated with drug resistance. The study concluded that combining chemotherapy drugs with VER could potentially improve the efficacy of treatment and reduce drug resistance.

Hope on the Horizon for Lung Cancer Treatment

This study holds significant promise for patients with NSCLC, offering a potential strategy to overcome drug resistance and improve treatment outcomes. The combination therapy, along with VER, could represent a valuable tool in the fight against this challenging cancer. Further research is warranted to fully evaluate the clinical implications of these findings.

A Sandcastle of Hope in a Sea of Cancer

Imagine a vast desert, where life is scarce, much like the challenges faced by NSCLC patients. This research offers a glimmer of hope, a sandcastle built with the potential to withstand the harsh tides of drug resistance. The combined therapy and VER represent a promising approach to combat this challenging disease.

Dr. Camel's Conclusion

This research highlights the potential of combining chemotherapy drugs with VER to enhance the efficacy of NSCLC treatment and overcome drug resistance. The findings offer a glimmer of hope for a future where NSCLC is effectively treated and patients have better outcomes.

Date :
  1. Date Completed 2018-08-27
  2. Date Revised 2019-03-05
Further Info :

Pubmed ID

29132176

DOI: Digital Object Identifier

10.1055/s-0043-117895

Related Literature

Article Analysis
・Effects of vinblastine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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