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Comparison of the Pharmacokinetics and Pharmacodynamics of Single-Dose Tenofovir Vaginal Film and Gel Formulation (FAME 05).

Author: BakshiRahul P, ColemanJenell S, FuchsEdward J, HendrixCraig W, MarzinkeMark A, RobinsonJennifer A, RohanLisa C, SpiegelHans M L

Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A single-dose tenofovir film demonstrated consistently higher concentrations in plasma and cervicovaginal samples when compared with tenofovir gel during the first day after dosing. Tenofovir film may provide an alternative to tenofovir oral and gel formulations. Clinical efficacy remains to be tested.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Although preexposure prophylaxis with oral tenofovir (TFV) disoproxil fumarate/emtricitabine reduces HIV acquisition rates, poor adherence to and acceptability of daily vaginal gels have led to development of vaginal film formulations to improve adherence and, potentially, to enable episo...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/29135651

データ提供：米国国立医学図書館（NLM）

Tenofovir Vaginal Film: A New Frontier in HIV Prevention

This research compares the pharmacokinetic and pharmacodynamic profiles of a new tenofovir vaginal film formulation to a previously studied tenofovir gel. It explores the potential of this new formulation to improve adherence and effectiveness in preventing HIV transmission. The study uses a crossover design, allowing researchers to directly compare the two formulations in a controlled setting.

Tenofovir Film: A Promising Alternative for HIV Prevention

The study reveals that tenofovir film demonstrates consistently higher concentrations of tenofovir in plasma and cervicovaginal fluid compared to the gel formulation. It highlights the potential of tenofovir film as a promising alternative to existing tenofovir formulations, offering improved bioavailability and potentially enhanced effectiveness for HIV prevention. This research is a significant step forward in the ongoing quest for safe and effective HIV prevention strategies.

HIV Prevention: Navigating the Desert of Risk

This research offers a new path in the vast desert of HIV prevention, demonstrating the potential of tenofovir film as a promising alternative to existing formulations. It encourages us to continue exploring new and innovative approaches to HIV prevention, striving to create a future where everyone has access to effective and user-friendly strategies for protecting themselves from this devastating virus.

Dr.Camel's Conclusion

This research guides us through the complex landscape of HIV prevention, unveiling the potential of tenofovir film as a promising new tool in the fight against this global health challenge. It encourages us to continue exploring innovative approaches to HIV prevention, paving the way for a future where everyone can navigate the desert of risk with greater protection and hope.

Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

29135651

DOI: Digital Object Identifier

NIHMS917323

Related Literature

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・Side Effects of emtricitabine
SNS
PICO Info
in preparation
Languages

English

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