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Analysis of Naturally Occurring Resistance-Associated Variants to NS3/4A Protein Inhibitors, NS5A Protein Inhibitors, and NS5B Polymerase Inhibitors in Patients With Chronic Hepatitis C.

Author: DaiMingjia, LiChunyang, ShenShanshan, SunDanhui, YanXuebing

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This review discusses the development and use of direct-acting antivirals (DAAs) for the treatment of hepatitis C virus (HCV) infection. DAAs have proven to be highly effective, but some patients may develop drug resistance mutations.
Paper Details　
Original Abstract of the Article :
The first NS3/4A hepatitis C virus (HCV) protease inhibitors telaprevir and boceprevir were approved in 2011, and both NS5A and NS5B polymerase inhibitors were launched. Recently, direct-acting antivirals (DAAs) have had a major impact on patients infected with HCV. HCV DAAs are highly effective ant...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5885147/

データ提供：米国国立医学図書館（NLM）

Hepatitis C Virus: Tackling Resistance to Direct-Acting Antivirals

The advent of [direct-acting antivirals (DAAs)] has revolutionized the treatment of [chronic hepatitis C (CHC)]. However, the emergence of [drug resistance mutations] poses a significant challenge. This study delves into the prevalence of [natural resistance] to DAAs in CHC patients. The researchers discovered that [resistance mutations] were present in treatment-naive patients, highlighting the need for careful monitoring and potential adjustments to treatment strategies.

The Ever-Evolving Landscape of Hepatitis C

The study reveals that the HCV virus is constantly evolving, adapting to new treatments. It's like navigating a shifting desert landscape, where the terrain is constantly changing. This underscores the importance of ongoing research and development to stay ahead of the virus.

Managing Drug Resistance: A Collaborative Effort

This research emphasizes the need for a [multidisciplinary approach] to managing drug resistance in CHC patients. This includes [genotyping, drug resistance testing, and personalized treatment strategies]. It's like a team of explorers working together to overcome the challenges of a difficult journey.

Dr. Camel's Conclusion

This study highlights the importance of ongoing vigilance in the fight against hepatitis C. Understanding the mechanisms of drug resistance is crucial for developing effective treatment strategies and ultimately achieving a cure.
Date :
  1. Date Completed 2019-05-29
  2. Date Revised 2023-11-05
Further Info :

Pubmed ID

29221500

DOI: Digital Object Identifier

PMC5885147

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・Effects of telaprevir
SNS
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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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