Fecal short-chain fatty acids at different time points after ceftriaxone administration in rats.

Author: HolotaYu V, HolubenkoO O, OstapchukA M, SerhiychukT M, TolstanovaG M, ZakordonetsL V

Paper Details 
Original Abstract of the Article :
Short-chain fatty acids (SCFAs) are major products of the microbial fermentation of dietary fiber in the colon. Recent studies suggest that these products of microbial metabolism in the gut act as signaling molecules, influence host energy homeostasis and play major immunological roles. In the prese...See full text at original site
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引用元:
https://doi.org/10.15407/ubj89.01.050

データ提供:米国国立医学図書館(NLM)

Antibiotics and Gut Bacteria: A Long-Term Impact

The delicate ecosystem of our gut, teeming with [microbes], plays a vital role in our overall health. This study explored the long-term effects of [antibiotics] on the [gut microbiome] in [rats]. Researchers administered [ceftriaxone] to [rats] for [14 days] and then monitored their [fecal short-chain fatty acid (SCFA) concentrations] over time. They found that [ceftriaxone] disrupted the [gut microbiome], causing a significant decrease in [SCFA concentrations] that persisted for several weeks.

Unraveling the Gut's Secret: The Impact of Antibiotics

The study reveals that [ceftriaxone] administration led to a significant reduction in [fecal SCFA concentrations], particularly [acetic, propionic, and butyric acids] – these are crucial components of the gut's ecosystem. The researchers observed a [time-dependent] decrease in [SCFA levels] that persisted even after [ceftriaxone] withdrawal, indicating a lasting impact on the [gut microbiome].

Beyond the Gut: Implications for Health

The study highlights the potential long-term effects of [antibiotic therapy] on the [gut microbiome] and underscores the importance of considering the gut's role in overall health. It's like a desert ecosystem - a single disturbance can disrupt the delicate balance and have far-reaching consequences. Further research is needed to understand the full extent of these effects and develop strategies for minimizing [gut microbiome] disruptions during [antibiotic therapy].

Dr. Camel's Conclusion

This study serves as a reminder that [antibiotics], while essential for treating infections, can have a significant impact on the [gut microbiome]. It's a delicate balance, much like navigating a desert ecosystem, where every element plays a vital role. Understanding this interaction is crucial for promoting gut health and overall well-being.

Date :
  1. Date Completed 2018-01-16
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29236389

DOI: Digital Object Identifier

10.15407/ubj89.01.050

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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