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Effectiveness of Protease Inhibitor/Nucleos(t)ide Reverse Transcriptase Inhibitor-Based Second-line Antiretroviral Therapy for the Treatment of Human Immunodeficiency Virus Type 1 Infection in Sub-Saharan Africa: A Systematic Review and Meta-analysis.

Author: BonnettLaura J, BoydMark A, CiaffiLaura, CollierAnn C, GerettiAnna Maria, JohnstonVictoria, PatonNicholas I, SaundersMatthew J, SchoffelenAnnelot F, StaffordKristen, StockdaleAlexander J, WandelerGilles

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This abstract highlights the need for outcome data on second-line antiretroviral therapy (ART) in sub-Saharan Africa to inform policy decisions in the face of growing need for this treatment.
Paper Details　
Original Abstract of the Article :
In sub-Saharan Africa, 25.5 million people are living with human immunodeficiency virus (HIV), representing 70% of the global total. The need for second-line antiretroviral therapy (ART) is projected to increase in the next decade in keeping with the expansion of treatment provision. Outcome data ar...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5982734/

データ提供：米国国立医学図書館（NLM）

Second-Line Antiretroviral Therapy: A Vital Oasis in the Desert of HIV Treatment

The global fight against HIV/AIDS is a relentless desert expedition, with millions facing the daunting challenges of this chronic infection. This study delves into the effectiveness of protease inhibitor/nucleos(t)ide reverse transcriptase inhibitor-based second-line antiretroviral therapy (ART) in sub-Saharan Africa, seeking a more sustainable and effective approach to managing this complex disease.

The authors conducted a comprehensive systematic review and meta-analysis, evaluating the effectiveness of second-line ART in this region. Their findings highlight the crucial role of second-line ART in maintaining viral suppression and improving health outcomes for individuals living with HIV.

A Lifeline in the Desert: Second-Line ART for Sustained Health

The study underscores the vital importance of second-line ART, like a well-placed oasis in a harsh desert environment, in providing individuals with HIV a lifeline to a healthier and more fulfilling life. This approach, like a reliable source of water, helps to sustain viral suppression and prevent disease progression, enabling individuals to live longer and healthier lives.

Navigating the Desert of HIV Treatment: A Collaborative Effort

The study also emphasizes the need for a collaborative approach to HIV treatment, involving healthcare providers, patients, and community organizations. This coordinated effort, like a well-organized desert expedition, is essential to ensuring that individuals have access to the necessary resources, support, and care, promoting a more sustainable and effective path to managing this chronic disease.

Dr.Camel's Conclusion

This study provides valuable insights into the effectiveness of second-line ART in sub-Saharan Africa. The findings highlight the crucial role of this therapy in maintaining viral suppression and improving health outcomes for individuals living with HIV. As we continue to navigate the desert of HIV treatment, we must remain committed to finding new and innovative solutions, ensuring that all those affected by this disease have access to the best possible care.

Date :
  1. Date Completed 2019-11-04
  2. Date Revised 2023-08-18
Further Info :

Pubmed ID

29272346

DOI: Digital Object Identifier

PMC5982734

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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