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Determinants of inappropriate empirical antibiotic treatment: systematic review and meta-analysis.

Author: CarraraElena, LeiboviciLeonard, PaulMical, PfefferIris, ZusmanOren

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This systematic review assessed study-level determinants of inappropriate empirical antibiotic treatment (IEAT), focusing on the influence of study years and the prevalence of multidrug-resistant organisms (MDROs). The review found that the prevalence of MDROs, particularly multidrug-resistant Gram-negative bacteria, was significantly associated with the probability of prescribing IEAT and higher mortality rates in recent studies.
Paper Details　
Original Abstract of the Article :
This systematic review assessed study-level determinants of non-covering (inappropriate) empirical antibiotic treatment (IEAT), focusing on the influence of study years and the prevalence of multidrug-resistant organisms (MDROs) in the study. Prospective and retrospective observational studies repor...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijantimicag.2017.12.013

データ提供：米国国立医学図書館（NLM）

Inappropriate Antibiotics: A Desert of Misguided Prescriptions

In the vast desert of medical practice, antibiotic use can be a double-edged sword. This systematic review and meta-analysis delves into the issue of inappropriate empirical antibiotic treatment (IEAT), examining the determinants of IEAT and its association with mortality in adult patients with microbiologically documented infections. The researchers analyzed data from prospective and retrospective observational studies published between 2008 and 2016, seeking to understand the factors that contribute to IEAT and its impact on patient outcomes.

IEAT: A Desert of Missed Targets in Antimicrobial Therapy

The review's findings highlight the alarming prevalence of IEAT, with a pooled event rate of 32% across the studies analyzed. The researchers identified a strong association between the prevalence of multidrug-resistant organisms (MDROs) and IEAT rates. This finding underscores the importance of carefully considering antibiotic resistance patterns in clinical practice, as it significantly impacts the likelihood of prescribing inappropriate antibiotics.

Navigating the Antibiotic Resistance Desert: A Look at IEAT

This research serves as a stark reminder of the growing challenge of antibiotic resistance. The review's findings emphasize the need for a more judicious approach to antibiotic use, taking into account the prevalence of MDROs and the potential consequences of inappropriate prescribing. This knowledge is essential for promoting responsible antibiotic stewardship and preventing the further spread of antibiotic resistance.

Dr. Camel's Conclusion

This review, like a lone camel trekking through the desert, guides us through the complex landscape of antibiotic use. The findings underscore the critical need for responsible antibiotic stewardship, highlighting the dangers of inappropriate prescribing and the urgent need to combat the growing challenge of antibiotic resistance.

Date :
  1. Date Completed 2018-08-28
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

29277528

DOI: Digital Object Identifier

10.1016/j.ijantimicag.2017.12.013

Related Literature

Article Analysis
・Effective treatment of antibiotic resistance
SNS
PICO Info
in preparation
Languages

English

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