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T-cell receptor excision circle levels and safety of paediatric immunization: A population-based self-controlled case series analysis.
Author: BulmanDennis E, ChakrabortyPranesh, CrowcroftNatasha S, DeeksShelley L, DuqueDaniel Rodriguez, HawkenSteven, KwongJeffrey, LittleJulian, MurphyMalia S Q, Pham-HuyAnne, PotterBeth K, WilsonKumanan
Original Abstract of the Article :
T-cell receptor excision circle levels are a surrogate marker of T-cell production and immune system function. We sought to determine whether non-pathological levels of infant T-cell receptor excision circles were associated with adverse events following immunization. A self-controlled case series d...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6037463/
データ提供:米国国立医学図書館(NLM)
T-Cell Receptor Excision Circles: A Vital Sign for Our Immune System
The field of immunology is constantly seeking new ways to assess immune function. This research delves into the role of T-cell receptor excision circles (TRECs) as a potential biomarker for immune health in infants. The study employed a self-controlled case series design, analyzing a vast dataset of 231,693 children in Ontario, Canada. The goal was to explore the link between TREC levels and adverse events following routine childhood vaccinations. This research utilized a clever method known as a self-controlled case series design, allowing researchers to compare each child’s vaccination outcomes to their own pre-vaccination status. This approach, similar to comparing the footprints of a camel in the desert, allowed them to pinpoint any subtle changes in immune response following vaccination. The researchers found no association between TREC levels and the occurrence of adverse events after vaccination. This finding provides valuable reassurance about the safety of routine immunizations.A Beacon of Safety for Routine Vaccinations
The study’s findings are encouraging, as they indicate that TREC levels, a measure of immune system function, don’t influence the likelihood of experiencing adverse events after vaccination. This provides valuable reassurance about the safety of routine immunizations in infants.Keeping Our Little Ones Safe: Insights from the Desert of Immunity
The desert of immunology is vast and complex, but this research shines a light on the safety of routinely administered pediatric vaccines. These findings offer a valuable resource for parents and healthcare providers, providing reassurance that vaccines are generally safe and effective, contributing to the well-being of our little ones.Dr.Camel's Conclusion
This research underscores the safety of routine childhood vaccinations by demonstrating no association between TREC levels and adverse events. This knowledge is crucial for maintaining public trust in vaccines, a vital tool for protecting our young ones from preventable diseases. Remember, just like a camel needs water in the desert, our children need vaccines to thrive in a world filled with infectious challenges.Date :
- Date Completed 2019-01-28
- Date Revised 2023-09-26
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