Side Effects of mmr vaccine: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Main Research Findings

The MMR vaccine is a safe and effective vaccine that protects children from measles, mumps, and rubella. 19 , 22 , 3 However, some studies have reported that there may be side effects after vaccination. 19 , 22 , 3

Reasons for Side Effects

The MMR vaccine is a live vaccine that contains weakened viruses for measles, mumps, and rubella. Therefore, after vaccination, there is a rare possibility of experiencing symptoms similar to these diseases. 19 , 22 , 3

Common Side Effects

Fever

Fever is one of the most common side effects. 1 , 20 , 3

Rash

Rash is another common side effect. 1 , 20 , 3

Pain and Swelling at the Injection Site

Pain and swelling at the injection site may also occur. 20

Other Side Effects

Symptoms such as headache, fatigue, joint pain, and loss of appetite may also occur. 20

Side Effects Management

Fever

If you are concerned about fever, consult a doctor and consider measures such as taking fever-reducing medication. 1 , 20 , 3

Rash

If a rash appears, consult a doctor. 1 , 20 , 3

Pain and Swelling at the Injection Site

If you are concerned about pain and swelling at the injection site, applying a cold compress may help reduce the symptoms. 20

Comparison of Studies

Commonalities

Many studies have shown that the MMR vaccine is safe and effective. 19 , 22 , 3

Differences

The frequency and symptoms of side effects vary from study to study. 19 , 22 , 3

Points to Note for Practical Application

The MMR vaccine is highly effective in protecting children from measles, mumps, and rubella. Vaccination significantly reduces the risk of contracting these diseases. 19 , 22 , 3

Limitations of Current Research

Research on the side effects of the MMR vaccine is still insufficient. 19 , 22 , 3

Future Research Directions

Further research on the long-term effects of the MMR vaccine and the mechanisms of side effects is necessary. 19 , 22 , 3

Conclusion

The MMR vaccine is a safe and effective vaccine that protects children from measles, mumps, and rubella. Vaccination significantly reduces the risk of contracting these diseases. However, side effects may occur in rare cases. If you are concerned about side effects, consult a doctor. 19 , 22 , 3

Literature analysis of 27 papers
Positive Content
25
Neutral Content
1
Negative Content
1
Article Type
6
0
0
3
25
1.

Effects and side effects of a new trivalent combined measles-mumps-rubella (MMR) vaccine.

Author: IsozakiM, Kuno-SakaiH, HoshiN, TakesueR, TakakuraI, KimuraM, HikinoM, MitsudaM

Seroconversion
Fever
Skin rash

The MMR vaccine is effective in inducing seroconversion against measles, mumps, and rubella. The most common side effects are fever and skin rash.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Measles, mumps and rubella vaccine 12 months after hematopoietic stem cell transplantation.

Author: RandiBruno Azevedo, FernandesEder Gatti, HigashinoHermes Ryoiti, LopesMarta Heloisa, RochaVanderson Geraldo, CostaSilvia Figueiredo, SartoriAna Marli Christovam

MMR vaccination

This retrospective study evaluated the timing of MMR vaccination after hematopoietic stem cell transplant (HSCT) and any reported side effects. Of 82 patients, 75.6% received the MMR vaccine before 23 months post-transplantation. None reported side effects. The data suggests that the MMR vaccination is safe from 12 to 23 months after HSCT.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

A comparative evaluation of therapeutic response in warts to intralesional vitamin D3 versus intralesional measles, mumps, and rubella vaccine.

Author: SinghAnant Kumar, DeviKonsam Nirupama, BistJitender S

Wart clearance
Side effects

This single-blind randomized control trial compared the therapeutic response and side effect profile of intralesional vitamin D3 and measles, mumps, and rubella (MMR) in treating cutaneous warts. The study found that both intralesional vitamin D3 and MMR are efficacious in treating cutaneous warts, with MMR agents being moderately better compared to vitamin D3.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A Randomized Comparative Study of MIP and MMR Vaccine for the Treatment of Cutaneous Warts.

Author: KaurAmandeep, BrarBalvinder Kaur, KumarSumir, BrarSukhmani Kaur, BoparaiAmarbir Singh, PuriNeerja

Wart resolution
Vaccine side effects

MIP intralesional injections were more effective than MMR for treating cutaneous warts, leading to faster resolution (9.41 vs 11.71 weeks). Both vaccines had side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Intralesional injection of Candida albicans antigen versus measles, mumps, and rubella vaccine for treatment of plantar warts.

Author: RagehRania Mahmoud, HewedyEl-Sayed Shaaban, HegabDoaa Salah

Candida albicans-specific antigen
Intralesional immunotherapy
MMR vaccine
Plantar warts
Wart recurrence

This study compared the efficacy of Candida albicans-specific antigen versus measles, mumps, and rubella (MMR) vaccine for treatment of plantar warts by intralesional injection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

The effects of scientific messages and narratives about vaccination.

Author: KuruOzan, SteculaDominik, LuHang, OphirYotam, ChanMan-Pui Sally, WinnegKen, Hall JamiesonKathleen, AlbarracínDolores

Vaccine confidence
Vaccine hesitancy

A study found that providing information about vaccine safety increased people's positive views about vaccines. However, messages about vaccine side effects may reduce the positive impact of the safety information.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Intralesional immunotherapy for the treatment of anogenital warts in pediatric population.

Author: NofalAhmad, AlakadRania

anogenital warts
intralesional immunotherapy

This study investigated the efficacy and safety of intralesional immunotherapy for treating multiple anogenital warts in children. The study found that both MMR vaccine and Candida antigen showed significantly better therapeutic response compared to saline. This suggests that intralesional immunotherapy is a promising and well-tolerated treatment option for anogenital warts in children.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Separating myths from reality for vaccines causing adverse events following immunization: an interview with Manish Sadarangani.

Author: SadaranganiManish

Prevent vaccine-preventable diseases

Dr Manish Sadarangani is a pediatric infectious diseases physician whose research focuses on immunization and vaccine-preventable diseases. His work links clinical trials with basic microbiology, immunology, and epidemiology to address clinically relevant problems.

BiographyA list of literature cited or referenced in a research paper or book. It shows the materials on which the research is based and is used to support the reliability of the paper.
Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
InterviewA conversation in the form of questions and answers, conducted one-on-one or with multiple people, to obtain information or perspectives.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Measles, mumps, and rubella vaccine in genital warts: A case report of two patients.

Author: MeenaDilip, SharmaShilpi, ChauhanPayal

Genital wart treatment
Side effects

Genital warts can have a significant psychological impact and are difficult to treat effectively. This report describes two cases of genital warts that responded well to intralesional treatment with the measles, mumps, and rubella (MMR) vaccine, offering a potential alternative therapy for patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

19.

T-cell receptor excision circle levels and safety of paediatric immunization: A population-based self-controlled case series analysis.

Author: WilsonKumanan, DuqueDaniel Rodriguez, MurphyMalia S Q, HawkenSteven, Pham-HuyAnne, KwongJeffrey, DeeksShelley L, PotterBeth K, CrowcroftNatasha S, BulmanDennis E, ChakrabortyPranesh, LittleJulian

Pediatric vaccination safety

This study found no association between newborn T-cell receptor excision circle levels and subsequent health services utilization events following routinely administered pediatric vaccines up to 15 months of age. These findings provide further support for the safety of pediatric vaccinations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Knowledge, attitudes and opinions towards measles and the MMR vaccine across two NSW cohorts.

Author: BriegerDaniel, EdwardsMatthew, MudgilPoonam, WhitehallJohn

Measles vaccination

Measles is a serious disease that can be prevented with vaccination. This study investigated parental knowledge and attitudes about measles and the MMR vaccine in New South Wales, Australia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

Two-year antibody persistence in children vaccinated at 12-15 months with a measles-mumps-rubella virus vaccine without human serum albumin.

Author: BerryAndrea A, Abu-ElyazeedRemon, Diaz-PerezClemente, MufsonMaurice A, HarrisonChristopher J, LeonardiMichael, TwiggsJerry D, PeltierChristopher, GroggStanley, CarbayoAntonio, ShapiroSteven, PoveyMichael, BaccariniCarmen, InnisBruce L, HenryOuzama

Measles protection
Mumps protection
Rubella protection
Vaccine safety
Febrile convulsion
Idiopathic thrombocytopenic purpura
Inguinal adenitis

This study investigated the persistence of antibodies against measles, mumps, and rubella in children who received one dose of either the M-M-R II or MMR-RIT vaccine at 12-15 months of age. Seropositivity for measles and rubella remained high at 2 years post-vaccination. Antibody persistence for mumps was also observed. Both vaccines were well-tolerated.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Immunogenicity and safety of a novel MMR vaccine (live, freeze-dried) containing the Edmonston-Zagreb measles strain, the Hoshino mumps strain, and the RA 27/3 rubella strain: Results of a randomized, comparative, active controlled phase III clinical trial.

Author: SoodAshwani, MitraMonjori, JoshiHimanshu Arvind, NayakUma Siddhartha, SiddaiahPrashanth, BabuT Ramesh, MahapatroSamarendra, SanmukhaniJayesh, GuptaGaurav, MittalRavindra, GlueckReinhard

Effective MMR vaccine
Safe for children
Fever
Rash

This phase III clinical trial evaluated the immunogenicity and safety of a novel MMR vaccine developed by Cadila Healthcare Limited, India, compared to an existing MMR vaccine developed by Serum Institute of India Limited, India. The novel vaccine was found to be non-inferior to the existing vaccine in terms of immunogenicity and safety.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Henoch-Schönlein purpura and drug and vaccine use in childhood: a case-control study.

Author: Da DaltLiviana, ZerbinatiClaudia, StrafellaMaria Stefania, RennaSalvatore, RiceputiLaura, Di PietroPasquale, BarabinoPaola, ScanferlaStefania, RaucciUmberto, MoresNadia, CompagnoneAdele, Da CasRoberto, Menniti-IppolitoFrancesca,

Henoch-Schönlein purpura

This study aimed to estimate the association of Henoch-Schönlein purpura (HSP), a common childhood vasculitis, with drug and vaccine administration in a pediatric population. While the etiology of HSP is unknown, infectious agents, drugs, and vaccines have been proposed as triggers.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

26.

Deaths following vaccination: What does the evidence show?

Author: MillerElaine R, MoroPedro L, CanoMaria, ShimabukuroTom T

Vaccine safety
Anaphylaxis
Eczema vaccinatum
Guillain-Barré syndrome
Intussusception
Progressive vaccinia

This study discussed the safety of vaccines in the United States, particularly in light of unsubstantiated claims of deaths caused by vaccines. The study reviewed epidemiologic data on deaths following vaccination, noting that while serious adverse reactions are rare, coincidental events do occur. The study emphasized the importance of relying on scientific evidence rather than anecdotal reports to assess vaccine safety.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

Risk communication of vaccines: challenges in the post-trust environment.

Author: BouderFrederic

Improved trust in vaccines

Public trust in immunization programs is fragile, often eroded by vaccine scares and misinformation. This article examines the principles of risk communication and provides policy recommendations for building public trust in immunization by employing a two-way proactive communication strategy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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