Paper Details

  1. Home
  2. Paper Details

Retreatment with sofosbuvir/velpatasvir in cirrhotic patients with genotype-4 who failed a previous interferon-free regimen: a case series.

Author: BoglioneLucio, CaritiGiuseppe, Di PerriGiovanni, LupiaTommaso, PinnaSimone Mornese

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Novel interferon-free regimens have significantly improved sustained virological response in chronic hepatitis C patients, without major side effects and with shorter treatment durations. However, treatment failure in a subset of patients was linked to resistance-associated substitutions, highlighting the need for further research on these mutations.
Paper Details　
Original Abstract of the Article :
The novel available interferon (IFN)-free regimens significantly improved the sustained virological response (SVR) in patients with chronic hepatitis C (CHC), without important side effects and with shorter duration of treatment. In a subset of patients, however, the treatment failure (TF) was due t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3851/IMP3226

データ提供：米国国立医学図書館（NLM）

Retreating from Hepatitis C with Sofosbuvir/Velpatasvir

Hepatitis C is a persistent infection, like a stubborn desert wind that refuses to die down. This study examines the effectiveness of retreatment with sofosbuvir/velpatasvir in cirrhotic patients with genotype 4 hepatitis C who failed a previous interferon-free regimen. The researchers analyzed a series of cases to evaluate the role of resistance-associated substitutions (RAS) in treatment failure and the potential for successful retreatment.

A Second Chance in the Desert

The study found that retreatment with sofosbuvir/velpatasvir was successful in achieving sustained virological response (SVR) in some patients who had previously failed interferon-free regimens. However, the presence of RAS was associated with treatment failure and relapse. This finding highlights the importance of identifying RAS and tailoring treatment strategies accordingly. It's like encountering a shifting sand dune in the desert, requiring a change in course to avoid getting lost.

Hope on the Horizon

This study offers hope for patients with hepatitis C who have failed previous treatment regimens. The effectiveness of sofosbuvir/velpatasvir in some cases suggests that retreatment with alternative therapies may be successful. However, it's crucial to carefully consider the potential for RAS and adjust treatment plans accordingly. It's like discovering a new oasis in the desert, providing a chance for healing and recovery.

Dr.Camel's Conclusion

This study provides a beacon of hope for patients with hepatitis C who have faced treatment challenges. It's like finding a hidden spring in the desert, offering a new source of strength and resilience in the fight against this persistent infection.

Date :
  1. Date Completed 2019-09-24
  2. Date Revised 2022-01-10
Further Info :

Pubmed ID

29442067

DOI: Digital Object Identifier

10.3851/IMP3226

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.