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The safety of iloprost in systemic sclerosis in a real-life experience.

Author: BartoliF, Bellando-RandoneS, BruniC, ColaciM, ConfortiM L, FerriC, FioriG, GiuggioliD, GuiducciS, LepriG, Matucci-CerinicM, Moggi-PignoneA, SpinellaA

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study evaluated the safety and tolerability of intravenous iloprost (ILO) treatment in patients with systemic sclerosis (SSc) with moderate Raynaud phenomenon (RP). 81 patients were sub-classified according to the edematous or fibrotic/atrophic cutaneous phase of the disease. Adverse events were more frequent in patients with digital edema, including painful swelling, flushing, and headache. Calcium channel blockers should be stopped while using ILO. In patients with digital edema, ILO infusion should be carefully employed after evaluating patient's drug tolerance.
Paper Details　
Original Abstract of the Article :
Iloprost (ILO) is employed intravenously for the treatment of severe Raynaud phenomenon (RP) and digital ulcers (DU) in systemic sclerosis (SSc). The aim of this study was to evaluate the safety and tolerability of the intravenous treatment with ILO in different phases of SSc. Eighty-one consecutive...See full text at original site
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引用元：
https://doi.org/10.1007/s10067-018-4043-0

データ提供：米国国立医学図書館（NLM）

The Safety and Effectiveness of Iloprost in Systemic Sclerosis

This study investigates the safety and tolerability of iloprost (ILO), a drug used intravenously to treat severe Raynaud phenomenon (RP) and digital ulcers (DU) in systemic sclerosis (SSc). Systemic sclerosis is a rare autoimmune disease that causes hardening and thickening of the skin and can affect internal organs. Researchers retrospectively evaluated 81 SSc patients with moderate RP who received iloprost infusions, analyzing the safety profile and tolerability of the drug based on the patients' skin phase (edematous or fibrotic/atrophic).

Iloprost: A Potential Treatment for Systemic Sclerosis, But With Potential Side Effects

The study found that iloprost was effective in treating RP and DU but experienced side effects, such as diarrhea and transient hypotension, during the infusion. Patients with digital edema were more likely to experience significant and painful digital swelling, flushing, and headache. The side effects were generally controlled by reducing the infusion rate. The researchers recommended that calcium channel blockers be temporarily stopped while using iloprost and that a pre-treatment approach could reduce or control adverse events.

Managing Systemic Sclerosis

This research emphasizes the importance of careful management of iloprost treatment in SSc patients. It's crucial to be aware of potential side effects and to closely monitor patients during the infusion process. If you have been diagnosed with SSc, consult with a healthcare professional to discuss appropriate treatment options and strategies for managing side effects.

Dr.Camel's Conclusion

Navigating the complexities of systemic sclerosis can be like traversing a vast desert, encountering unexpected challenges along the way. This research highlights the potential benefits of iloprost in treating SSc but emphasizes the importance of careful monitoring and individualized management to minimize risks and maximize therapeutic outcomes. Remember, working closely with healthcare professionals is key to navigating this complex condition.

Date :
  1. Date Completed 2018-09-18
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

29470737

DOI: Digital Object Identifier

10.1007/s10067-018-4043-0

Related Literature

Article Analysis
・Side Effects of iloprost
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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