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Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery.

Author: AtkinTobias, ComaiStefano, GobbiGabriella

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review analyzes the neurobiological and clinical evidence of pharmacological treatments of insomnia, excluding the benzodiazepines (BZDs) and Z-drugs.
Paper Details　
Original Abstract of the Article :
Although the GABAergic benzodiazepines (BZDs) and Z-drugs (zolpidem, zopiclone, and zaleplon) are FDA-approved for insomnia disorders with a strong evidence base, they have many side effects, including cognitive impairment, tolerance, rebound insomnia upon discontinuation, car accidents/falls, abuse...See full text at original site
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引用元：
https://doi.org/10.1124/pr.117.014381

データ提供：米国国立医学図書館（NLM）

Beyond Benzodiazepines: Exploring New Medications for Insomnia

Insomnia, a common sleep disorder, can have a significant impact on overall health and well-being. This study provides a comprehensive overview of current and emerging pharmacological treatments for insomnia, focusing on alternatives to the traditional [benzodiazepines (BZDs)] and [Z-drugs]. The researchers examine the neurobiological mechanisms of action, clinical applications, and potential side effects of various medications used to treat insomnia.

Expanding the Treatment Options for Insomnia: A New Frontier in Sleep Medicine

This study explores a wide range of promising medications, including [melatonergic agonists], [orexin receptor antagonists], [calcium channel modulators], and [antihistamines]. The researchers highlight the importance of personalized medicine, emphasizing that different medications may be more effective for different individuals based on their specific sleep difficulties.

Understanding Insomnia: A Journey Towards Better Sleep

This research provides valuable insights into the complex nature of insomnia and the importance of exploring a range of treatment options. By understanding the mechanisms behind these medications and their potential benefits and risks, healthcare providers can develop individualized treatment plans that promote healthy sleep for individuals suffering from insomnia.

Dr.Camel's Conclusion

Just like camels have adapted to thrive in environments with limited water, individuals with insomnia are constantly seeking strategies for achieving restful sleep. This study provides a roadmap for exploring a wide array of treatment options, paving the way for a more fulfilling and restorative sleep experience.

Date :
  1. Date Completed 2018-12-11
  2. Date Revised 2018-12-11
Further Info :

Pubmed ID

29487083

DOI: Digital Object Identifier

10.1124/pr.117.014381

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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