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Design of a Topically Applied Gel Spray Formulation with Ivermectin Using a Novel Low Molecular Weight Gelling Agent, Palmitoyl-Glycine-Histidine, to Treat Scabies.
Author: DahlizarSabrina, FutakiMika, KadhumWesam Radhi, OkadaAkie, SugibayashiKenji, TodoHiroaki
Original Abstract of the Article :
Palmitoyl-glycine-histidine (Pal-GH) is a new low molecular weight gelling agent. It exhibits thixotropic behavior, low viscosity, and high dissolving properties for a wide range of hydrophilic to lipophilic drugs. Orally administered ivermectin (IVM) is used to treat scabies. However, this treatmen...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1248/cpb.c17-00965
データ提供:米国国立医学図書館(NLM)
Scabies Treatment: A New Approach to Combating an Itchy Desert
Scabies, a skin infestation, can be a real itch in the desert of our lives. Ivermectin, a commonly used medication for scabies, is typically administered orally. However, this route can lead to side effects. This research explores a new approach, investigating the potential of a topically applied gel spray formulation containing ivermectin to treat scabies. The researchers formulated a gel spray using a novel gelling agent, palmitoyl-glycine-histidine (Pal-GH), and evaluated its effectiveness in delivering ivermectin to the skin of hairless rats.
A Oasis of Innovation: Topical Ivermectin Delivery
This study presents a novel approach to scabies treatment, potentially offering an alternative to oral administration with fewer side effects.
A Gentle Breeze Across the Desert: Treating Scabies Effectively
The research suggests that topical delivery of ivermectin using a Pal-GH gel spray formulation may offer a more effective and potentially safer approach to treating scabies.
Dr.Camel's Conclusion
Scabies can feel like an endless itch in the desert. This research explores a new way to combat this pesky condition, potentially offering a more comfortable and effective treatment option. The innovative use of a gel spray formulation may bring a new wave of relief to those struggling with this common condition.
Date :
- Date Completed 2018-03-27
- Date Revised 2018-03-27
Further Info :
Related Literature
English
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