An update on the safety of current therapies for Alzheimer's disease: focus on rivastigmine.

Author: GrossbergGeorge T, KhouryRita, RajamanickamJayashree

Paper Details 
Original Abstract of the Article :
Alzheimer's disease (AD) is the most common cause of major neurocognitive disorders worldwide. Despite all research efforts, therapeutic options for AD are still limited to two drug classes: cholinesterase inhibitors (ChEIs) and the NMDA-receptor antagonist memantine. Donepezil, rivastigmine and gal...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5810854/

データ提供:米国国立医学図書館(NLM)

Rivastigmine for Alzheimer's Disease: A Journey Through the Sands of Memory

Alzheimer's disease (AD), a relentless desert of cognitive decline, is a global health concern. While research continues, treatments for AD remain limited to cholinesterase inhibitors (ChEIs) and memantine. This review focuses on rivastigmine, a ChEI available in both oral and transdermal patch formulations, like two different paths through the desert, each with its own advantages and challenges. Although rivastigmine has unique characteristics, it has been associated with a higher incidence of side effects, particularly gastrointestinal problems with the oral form. The transdermal patch, however, offers a more tolerable option for managing AD, although skin reactions may occur. It is crucial to be aware of the potential for overdose with the patch and to use it as prescribed.

Navigating the Sands of AD

This review highlights the potential benefits and challenges of using rivastigmine for AD. While rivastigmine offers a potential treatment option for AD, its safety profile needs careful consideration. The transdermal patch formulation may be a more tolerable option for some patients, but it's essential to follow instructions closely and be aware of potential side effects. The search for better and safer therapies for AD continues, like a tireless camel seeking a hidden oasis in the vast expanse of the disease.

Living with AD: A Journey of Hope

AD is a challenging disease, but it is important to remember that hope exists. There are ongoing research efforts to develop new and effective treatments for AD. If you or someone you know is living with AD, it is essential to seek professional medical advice and explore the available treatment options. Remember, like the desert, AD can be vast and complex, but with the right support, there is hope for a brighter future.

Dr. Camel's Conclusion

Rivastigmine, a ChEI for Alzheimer's disease, presents both potential benefits and challenges. While the transdermal patch formulation offers a more tolerable option, careful monitoring and education about potential side effects are crucial. Remember, the journey through the desert of Alzheimer's is long and winding, but it is not without hope.
Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

29492246

DOI: Digital Object Identifier

PMC5810854

SNS
PICO Info
in preparation
Languages

English

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