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Outcome of a three-phase treatment algorithm for inpatients with melancholic depression.

Author: BirkenhägerTom K, HoogendijkWitte J G, KampermanAstrid M, VermeidenMarlijn, van den BroekWalter W

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A 3-phase treatment algorithm, involving optimal antidepressant monotherapy followed by lithium addition and then electroconvulsive therapy if necessary, led to complete remission in 46% of inpatients with major depressive disorder.
Paper Details　
Original Abstract of the Article :
BACKGROUND: In patients suffering from major depressive disorder, non-response to initial antidepressant monotherapy is relatively common. The use of treatment algorithms may optimize and enhance treatment outcome. METHODS: A single-center 3-phase treatment algorithm was evaluated for inpatients wi...See full text at original site
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引用元：
https://doi.org/10.1016/j.pnpbp.2018.03.002

データ提供：米国国立医学図書館（NLM）

A Multi-Phase Treatment Algorithm for Melancholic Depression

Melancholy depression, a severe form of major depressive disorder, can pose significant challenges for treatment. This research evaluates the effectiveness of a three-phase treatment algorithm for inpatients with melancholic depression, involving sequential steps of antidepressant monotherapy, lithium augmentation, and electroconvulsive therapy (ECT).

Optimizing Treatment for Melancholic Depression

The researchers examined the feasibility and efficacy of a multi-phase treatment algorithm for melancholic depression. They found that the algorithm was associated with significant improvement in depressive symptoms, achieving complete remission in nearly half of the patients.

Improving Outcomes for Patients with Melancholic Depression

The study's findings suggest that a multi-phase treatment algorithm can be an effective approach for managing melancholic depression. By employing a stepwise approach, clinicians can tailor treatment strategies to the individual needs of patients, potentially leading to better outcomes.

Dr.Camel's Conclusion

This research offers a beacon of hope for individuals battling melancholic depression. By exploring the effectiveness of a multi-phase treatment algorithm, the study provides a framework for improving patient outcomes and enhancing the management of this challenging condition.
Date :
  1. Date Completed 2019-02-14
  2. Date Revised 2019-02-15
Further Info :

Pubmed ID

29505804

DOI: Digital Object Identifier

10.1016/j.pnpbp.2018.03.002

Related Literature

Article Analysis
・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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