Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Study of Fruquintinib After Two Prior Chemotherapy Regimens in Chinese Patients With Advanced Nonsquamous Non‒Small-Cell Lung Cancer.

Author: AnTongtong, ChangJianhua, ChenMo, HuaYe, LiWei, LiuXiaoqing, LiuZhe, LuShun, LuYou, ShiJianhua, SuWeiguo, WangJie, YangJin-Ji, YangLei, ZhouJianying, ZhouXiangdong

Paper Details 
Original Abstract of the Article :
Purpose Patients with advanced non‒small-cell lung cancer (NSCLC) who fail two lines of chemotherapy have unmet medical needs. The kinase inhibitor fruquintinib selectively targets vascular endothelial growth factor receptors and, hence, tumor angiogenesis and lymphogenesis. This randomized, double-...See full text at original site
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引用元:
https://doi.org/10.1200/JCO.2017.76.7145

データ提供:米国国立医学図書館(NLM)

Fruquintinib for Advanced Non-Small Cell Lung Cancer: A Phase II Trial

Advanced non-small cell lung cancer (NSCLC), a formidable foe in the battle against cancer, often presents a significant challenge for treatment. This study, a phase II trial, evaluates the efficacy and safety of fruquintinib, a targeted therapy like a skilled archer aiming at specific targets in the desert of cancer cells, in patients with advanced NSCLC who have progressed after two prior chemotherapy regimens. The researchers investigated the effectiveness and potential side effects of fruquintinib in this challenging patient population.

A Targeted Approach: Evaluating Fruquintinib in Advanced NSCLC

The researchers found that fruquintinib, a targeted therapy for advanced NSCLC, demonstrated promising results in terms of progression-free survival and objective response rate. The study found that fruquintinib significantly prolonged progression-free survival compared to placebo, suggesting that it could offer a valuable treatment option for patients with advanced NSCLC who have exhausted other therapies. The researchers also noted that fruquintinib was generally well-tolerated, with manageable side effects.

Navigating the Desert of Cancer Treatment: Seeking New Therapies

Advanced NSCLC can be a challenging diagnosis, leaving patients seeking new and effective treatment options. This study provides evidence that fruquintinib may offer a promising therapeutic approach, providing hope for patients facing this difficult journey. The researchers encourage further research to confirm these findings and explore the potential of fruquintinib in combination with other therapies.

Dr. Camel's Conclusion

The desert of cancer treatment can be a daunting landscape, with patients often seeking new and effective therapies. This study explores the potential of fruquintinib, a targeted therapy for advanced NSCLC. The researchers found that fruquintinib demonstrated promising results in terms of progression-free survival and objective response rate. While further research is needed, the study suggests that fruquintinib could offer a valuable treatment option for patients facing this challenging diagnosis. As a wise camel, I believe that continued exploration and innovation are essential in the fight against cancer, and this study offers a glimmer of hope for patients seeking new avenues of treatment.
Date :
  1. Date Completed 2019-08-01
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

29528793

DOI: Digital Object Identifier

10.1200/JCO.2017.76.7145

Related Literature

SNS
PICO Info
in preparation
Languages

English

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