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Are There Benefits in Adding Catechol-O Methyltransferase Inhibitors in the Pharmacotherapy of Parkinson's Disease Patients? A Systematic Review.

Author: KatsaitiIrene, NixonJohn

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

A combination of levodopa with a medication that prevents its breakdown in the body is the best treatment for Parkinson's disease (PD). However, as the disease progresses, the effectiveness of levodopa decreases. Medications that increase the amount of levodopa available in the body can help extend the benefits of levodopa treatment.
Paper Details　
Original Abstract of the Article :
A qualified consensus suggests that a combination of levodopa with a peripherally acting dopa decarboxylase inhibitor continues to present the gold standard treatment of Parkinson's disease (PD). However, as the disease progresses the therapeutic window of levodopa becomes narrowed. Pharmacological ...See full text at original site
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引用元：
https://doi.org/10.3233/JPD-171225

データ提供：米国国立医学図書館（NLM）

A Deeper Look into Parkinson's Disease: Exploring the Benefits of COMT Inhibitors

Parkinson's disease, a neurodegenerative disorder that affects movement, is a complex condition that requires ongoing research to develop effective treatments. This research examines the potential benefits of adding catechol-O-methyltransferase (COMT) inhibitors to the pharmacotherapy of Parkinson's disease patients. It's like searching for a new oasis in the vast desert of Parkinson's research, seeking to improve the lives of those affected by this debilitating disease.

COMT Inhibitors: A Potential Solution for Motor Fluctuations

The review suggests that COMT inhibitors, by improving the bioavailability of levodopa, the gold standard treatment for Parkinson's disease, may offer a valuable solution for managing motor fluctuations. It's like discovering a new method for transporting water through the desert, ensuring a more consistent and effective supply to those in need.

Managing Parkinson's Disease: A Continuous Journey

This research underscores the ongoing need for research and development of new therapies for Parkinson's disease. It highlights the importance of exploring new strategies to manage the challenges associated with this complex disorder. It's like a journey across a vast and challenging desert, where each new discovery brings us closer to a more sustainable and resilient future for those affected by Parkinson's disease.

Dr.Camel's Conclusion

This research on the potential benefits of COMT inhibitors in Parkinson's disease is a reminder that the search for effective treatments for this complex disorder is an ongoing journey. It offers hope that by exploring new avenues, we can continue to improve the lives of those affected by Parkinson's disease. It's like navigating a challenging desert landscape, where each new discovery brings us closer to a more sustainable and resilient future.

Date :
  1. Date Completed 2019-10-16
  2. Date Revised 2019-10-16
Further Info :

Pubmed ID

29614697

DOI: Digital Object Identifier

10.3233/JPD-171225

SNS
PICO Info
in preparation
Languages

English

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