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Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study.

Author: AlphsLarry, CanusoCarla M, DrevetsWayne C, FedgchinMaggie, HoughDavid, LaneRosanne, LimPilar, ManjiHusseini, PinterChristine, SanacoraGerard, SinghJaskaran B

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Intranasal esketamine, given in addition to standard-of-care treatment, may result in rapid improvement in depressive symptoms, including some measures of suicidal ideation, among depressed patients at imminent risk for suicide.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The authors compared the efficacy of standard-of-care treatment plus intranasal esketamine or placebo for rapid reduction of symptoms of major depression, including suicidality, among individuals at imminent suicide risk. METHOD: In a double-blind, multicenter, proof-of-concept study, 68...See full text at original site
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引用元：
https://doi.org/10.1176/appi.ajp.2018.17060720

データ提供：米国国立医学図書館（NLM）

Esketamine: A Rapid Relief for Depression and Suicidality

Depression is a debilitating mental health condition that can lead to suicidal thoughts and behaviors. This study investigates the efficacy of intranasal esketamine as a rapid-acting treatment for depression and suicidality in individuals at imminent suicide risk. The authors conducted a double-blind, randomized, placebo-controlled trial to compare the effects of esketamine to placebo in patients receiving standard-of-care treatment.

Esketamine: A Potential Game-Changer for Depression Treatment

The research provides promising evidence for esketamine's potential as a rapid-acting treatment for depression and suicidality. The study found that esketamine significantly improved depressive symptoms, including measures of suicidal ideation, in patients at imminent suicide risk. These findings suggest that esketamine could offer a valuable tool for managing acute episodes of depression and suicidal thoughts. It’s like finding a refreshing spring in the desert, providing a sense of relief and hope.

Navigating the Path to Mental Health Recovery

This research emphasizes the importance of developing effective and rapid-acting treatments for depression and suicidality. The study's findings provide a strong rationale for further investigation into the therapeutic potential of esketamine. It is crucial to remember that mental health recovery is a journey, and the right treatment options can play a vital role in navigating this path.

Dr.Camel's Conclusion

The study highlights the potential of esketamine for rapid relief of depression and suicidality, offering hope for individuals struggling with these debilitating conditions. Like a camel who endures the harsh desert environment, individuals with depression and suicidal thoughts can find strength and resilience with the right support and treatment.

Date :
  1. Date Completed 2019-07-08
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

29656663

DOI: Digital Object Identifier

10.1176/appi.ajp.2018.17060720

Related Literature

Article Analysis
・Effective treatment of suicide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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