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Clozapine-Induced Cardiovascular Side Effects and Autonomic Dysfunction: A Systematic Review.

Author: BarrAlasdair M, HonerWilliam G, KimDavid D, ProcyshynRic M, WhiteRandall F, YuenJessica W Y

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Clozapine is the best treatment for schizophrenia that doesn’t respond to other medications, but it has many side effects. This review of studies about clozapine found that it can cause heart problems. This is because clozapine affects the nervous system and can cause changes in heart rate and blood pressure. The review highlighted the need for more research to better understand clozapine's effect on the nervous system and to develop better ways to prevent and manage its side effects.
Paper Details　
Original Abstract of the Article :
<b>Background:</b> Clozapine is the antipsychotic of choice for treatment-resistant schizophrenia and has minimal risk for extrapyramidal symptoms. Therapeutic benefits, however, are accompanied by a myriad of cardiometabolic side-effects. The specific reasons for clozapine's high propensity to cau...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893810/

データ提供：米国国立医学図書館（NLM）

Navigating the Cardiovascular Landscape of Clozapine Treatment

Schizophrenia, a complex mental illness, often requires specialized treatment approaches. Clozapine, an antipsychotic medication, has proven effective for patients with treatment-resistant schizophrenia. However, clozapine is known to be associated with significant cardiometabolic side effects, raising concerns about its long-term impact on cardiovascular health. This study delves into the intricate relationship between clozapine and autonomic dysfunction, a key player in the development of cardiovascular complications.

Untangling the Complexities of Clozapine and Autonomic Dysfunction

The study examines the existing research on clozapine-induced cardiovascular side effects, revealing a significant gap in our understanding of how this medication impacts the autonomic nervous system. It highlights the need for more robust clinical trials and the development of targeted interventions to manage these cardiovascular risks. The authors call for a multi-pronged approach to mitigate the potential harm associated with clozapine, including improved monitoring and novel treatment strategies.

A Call for Deeper Understanding and Effective Management Strategies

This study emphasizes the critical need for comprehensive research to understand the complex interplay between clozapine and the autonomic nervous system. By gaining a deeper understanding of this interaction, researchers can develop safer and more effective treatment approaches for patients with schizophrenia, ensuring that their mental health is addressed while minimizing cardiovascular risks.

Dr.Camel's Conclusion

Just as a camel navigates a vast and sometimes treacherous desert, we must carefully navigate the complex landscape of clozapine treatment. This study serves as a reminder that a thorough understanding of the potential risks and benefits is crucial for ensuring the well-being of patients with schizophrenia.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-10-01
Further Info :

Pubmed ID

29670504

DOI: Digital Object Identifier

PMC5893810

SNS
PICO Info
in preparation
Languages

English

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