Theobromine Does Not Affect Fasting and Postprandial HDL Cholesterol Efflux Capacity, While It Decreases Fasting miR-92a Levels in Humans.

Author: BakerootVirginie, MensinkRonald P, PlatJogchum, SmoldersLotte, TalbotCharlotte P J

Paper Details 
Original Abstract of the Article :
Chocolate consumption lowers cardiovascular disease risk, which might be attributed to the methylxanthine theobromine. These effects may be mediated through effects on HDL-mediated cholesterol efflux, which may be affected by microRNA (miRNA) levels in the HDL particles. Therefore, the aim of this s...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6055688/

データ提供:米国国立医学図書館(NLM)

Theobromine and HDL Cholesterol: A Culinary Journey in the Desert of Cardiovascular Health

Chocolate, a beloved indulgence, has been linked to a lower risk of cardiovascular disease. This study, exploring the potential benefits of theobromine, a key component of chocolate, investigates its impact on HDL-mediated cholesterol efflux. The researchers examined the effects of theobromine consumption on both fasting and postprandial cholesterol efflux, as well as its influence on miRNA levels in HDL particles.

Theobromine: A Potential Ally in Cardiovascular Health

The study's findings suggest that while theobromine does not significantly affect HDL cholesterol efflux capacity, it does exhibit a reduction in fasting miR-92a levels. These findings open doors to further exploration of the potential mechanisms by which theobromine might contribute to cardiovascular health, particularly in relation to its impact on miRNA levels within HDL particles.

Navigating the Cardiovascular Health Desert: A Look at Theobromine

This research sheds light on the complex relationship between theobromine and HDL cholesterol. The study's findings, while not conclusive, suggest that theobromine's influence on HDL-mediated cholesterol efflux may be more nuanced than initially thought. Further research is needed to fully understand the potential benefits of theobromine, particularly in relation to its impact on miRNA levels and its role in cardiovascular health.

Dr. Camel's Conclusion

This study takes us on a delectable journey through the desert of cardiovascular health, exploring the potential benefits of theobromine. While the findings suggest that theobromine's impact on HDL cholesterol efflux may not be as straightforward as initially believed, the research opens doors to further investigation, potentially leading to a deeper understanding of its role in maintaining cardiovascular health.

Date :
  1. Date Completed 2019-01-30
  2. Date Revised 2023-09-26
Further Info :

Pubmed ID

29797695

DOI: Digital Object Identifier

PMC6055688

Related Literature

SNS
PICO Info
in preparation
Languages

English

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