Paper Details

  1. Home
  2. Paper Details

Survival times in dogs with presumptive intracranial gliomas treated with oral lomustine: A comparative retrospective study (2008-2017).

Author: CohenP W, DeweyC W, MoiranoS J, WrightK Z

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This retrospective study investigated the effectiveness of lomustine chemotherapy in treating intracranial gliomas in dogs. Dogs treated with lomustine lived longer than those treated exclusively with symptomatic care. Lomustine-associated side effects were common but rarely life-threatening. This study suggests that lomustine therapy may be a valuable treatment option for dogs with intracranial gliomas.
Paper Details　
Original Abstract of the Article :
Intracranial gliomas are a common malignancy in dogs, and are associated with a poor prognosis due to their aggressive nature and a lack of clinically effective treatments. The efficacies of various treatment modalities for canine brain tumours have been previously described, though little data exis...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/vco.12401

データ提供：米国国立医学図書館（NLM）

Lomustine for Canine Intracranial Gliomas: A Beacon of Hope in a Challenging Landscape

This retrospective study examines the use of [lomustine] chemotherapy in the treatment of [intracranial gliomas] in dogs. The researchers compared the survival times of dogs treated with lomustine to those treated with symptomatic care only.

A New Trail in the Desert: Lomustine and Canine Gliomas

The study revealed that dogs treated with lomustine chemotherapy had significantly longer survival times compared to those receiving symptomatic care. This suggests that lomustine may offer a valuable treatment option for canine gliomas, akin to discovering a new trail that leads to a hidden oasis in the desert.

Navigating the Challenges: Lomustine Side Effects and Prognostic Factors

While lomustine showed promise, the study also identified potential side effects, such as [neutropenia, anemia, thrombocytopenia, and potential renal and hepatotoxicity]. The researchers found that a longer duration of clinical signs prior to diagnosis was associated with a longer survival time. This underscores the importance of early diagnosis and intervention in managing this challenging disease.

Dr.Camel's Conclusion

This study provides valuable insight into the potential benefits of lomustine chemotherapy for canine gliomas. It reminds us that even in the harsh landscape of cancer, we can find new pathways and treatments that provide hope and extend survival. While the journey may be challenging, the rewards of discovery can be immense.

Date :
  1. Date Completed 2018-11-27
  2. Date Revised 2018-11-27
Further Info :

Pubmed ID

29797768

DOI: Digital Object Identifier

10.1111/vco.12401

Related Literature

Article Analysis
・Side Effects of lomustine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.