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Retinoic acid elicits a coordinated expression of gut homing markers on T lymphocytes of Zambian men receiving oral Vivotif, but not Rotarix, Dukoral or OPVERO vaccines.

Author: BandaRose, BesaEllen C, ChamaMubanga, ChilengiRoma, ChombaMumba S, FunjikaEvelyn, HancockRobert E W, ImikenduMercy, KellyPaul M, LeeAmy, Mwanza-LisuloMpala, NamangalaBoniface, SianongoSandie, StaggAndy J, ZyamboKanekwa

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study showed that all-trans retinoic acid (ATRA) increased the expression of gut homing markers α4β7 integrin and CCR9 on T cells in healthy adult volunteers. This coordinated increase was observed in 57% of volunteers and only when ATRA was given together with an oral Vivotif vaccine. The coordinated response was strongly correlated with the gut IgA specific response to vaccine LPS. These results suggest that ATRA may be used to manipulate responses to oral vaccines, such as the live attenuated Vivotif vaccine.
Paper Details　
Original Abstract of the Article :
All-trans retinoic acid (ATRA) up-regulates, in laboratory animals, the expression of the gut homing markers α4β7 integrin and CCR9 on lymphocytes, increasing their gut tropism. Here, we show that, in healthy adult volunteers, ATRA induced an increase of these gut homing markers on T cells in vivo i...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020133/

データ提供：米国国立医学図書館（NLM）

Manipulating Immune Responses: A New Approach to Vaccine Development

Vaccines are a cornerstone of public health, protecting individuals from infectious diseases. This study explores the potential of retinoic acid (ATRA), a naturally occurring compound, to enhance the effectiveness of oral vaccines. It's like discovering a hidden key that unlocks the potential of a desert oasis, making its resources more readily available.

A Specific Response: A Targeted Approach

The study found that ATRA, when given with a specific oral vaccine (Vivotif), induced an increase in gut homing markers on T cells. These markers help immune cells target the gut, where many infections occur. It's like finding a way to create a specific route through the desert, directing resources to the areas most in need.

Beyond Vivotif: Further Exploration

This study suggests that ATRA could be used to enhance the effectiveness of specific oral vaccines. Further research is needed to explore its potential with other vaccines and understand the mechanisms behind this enhanced immune response. It's like opening a new chapter in the exploration of the desert, revealing new pathways and possibilities.

Dr.Camel's Conclusion

This study offers a glimpse into the future of vaccine development, where the immune system can be strategically manipulated to achieve greater protection. It's like learning to harness the power of the desert winds, channeling their force to create a more hospitable environment for those living within its boundaries.
Date :
  1. Date Completed 2018-10-01
  2. Date Revised 2018-11-14
Further Info :

Pubmed ID

29801999

DOI: Digital Object Identifier

PMC6020133

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Languages

English

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