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Efficacy, acceptability, and tolerability of antipsychotics in children and adolescents with schizophrenia: A network meta-analysis.

Author: BighelliIrene, ChaimaniAnna, HuhnMaximilian, KrauseMarc, LeuchtStefan, Schneider-ThomaJohannes, ZhuYikang

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This network-meta-analysis of 28 randomized controlled trials (RCTs) involving 3003 participants with schizophrenia found that clozapine was significantly more effective than other antipsychotics, while ziprasidone showed no efficacy. Most antipsychotics were more effective than placebo, but there were evidence gaps for some drugs and outcomes, particularly safety outcomes.
Paper Details　
Original Abstract of the Article :
Children and adolescents with schizophrenia are a particularly vulnerable group. Thus, we integrated all the randomized evidence from the available antipsychotics used for this subgroup by performing a network-meta-analysis and pairwise meta-analysis using a random-effects model. We searched multipl...See full text at original site
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引用元：
https://doi.org/10.1016/j.euroneuro.2018.03.008

データ提供：米国国立医学図書館（NLM）

Antipsychotics for Schizophrenia in Children and Adolescents: A Desert of Uncertainty

Schizophrenia is a serious mental illness that can have a devastating impact on individuals and their families. This study explores the efficacy and tolerability of various antipsychotic medications for treating schizophrenia in children and adolescents. It's like navigating a vast and uncertain desert, where researchers are seeking the best path to treat this complex condition.

The study found that clozapine was significantly more effective than all other antipsychotics analyzed. Most antipsychotics were more efficacious than placebo, but ziprasidone showed no efficacy. The study also examined side effects such as weight gain, sedation, and prolactin increase, finding that different medications had different profiles.

Antipsychotics: A Balancing Act in Treating Schizophrenia

This study highlights the need for careful consideration of medication choices when treating schizophrenia in children and adolescents. The findings emphasize the importance of weighing efficacy against potential side effects and selecting the medication that is best suited for the individual patient.

Schizophrenia Treatment: Navigating the Sands of Uncertainty

Schizophrenia is a complex and challenging condition. This study offers valuable insights into the effectiveness and tolerability of various antipsychotic medications. The findings highlight the importance of careful medication selection and monitoring to ensure optimal outcomes.

Dr. Camel's Conclusion

This research investigates the use of antipsychotics for treating schizophrenia in children and adolescents, a complex and challenging condition. It's like navigating a vast and uncertain desert, where researchers are seeking the best path to treat this complex condition. The study's findings emphasize the need for careful medication selection and monitoring to ensure optimal outcomes for young people with schizophrenia.

Date :
  1. Date Completed 2019-03-22
  2. Date Revised 2019-03-22
Further Info :

Pubmed ID

29802039

DOI: Digital Object Identifier

10.1016/j.euroneuro.2018.03.008

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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