Paper Details

  1. Home
  2. Paper Details

A Phase III Randomized Placebo-Controlled Trial to Evaluate Efficacy and Safety of Romosozumab in Men With Osteoporosis.

Author: BlicharskiTomasz, ChenLi, GoemaereStefan, HorlaitStephane, LewieckiE Michael, LippunerKurt, MaddoxJudy, MeisnerPaul D, MillerPaul D, MiyauchiAkimitsu

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Romosozumab significantly increased bone mineral density (BMD) in the spine and hip of men with osteoporosis compared to placebo, with a good safety profile.
Paper Details　
Original Abstract of the Article :
CONTEXT: Globally, one in five men aged >50 years is predicted to experience an osteoporotic fracture. Because of the treatment gap in osteoporosis and the paucity of bone-forming agents for men, new osteoporosis treatments are needed. OBJECTIVE: To evaluate the safety and efficacy of romosozumab i...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1210/jc.2017-02163

データ提供：米国国立医学図書館（NLM）

Romosozumab: A New Hope for Men with Osteoporosis

This research explores the vast and often treacherous landscape of osteoporosis, a condition that affects millions of men worldwide. The study examines the potential of romosozumab, a novel bone-forming agent, to treat osteoporosis in men. The researchers conducted a double-blind, placebo-controlled trial with 245 men, a group as diverse as the flora and fauna of a desert ecosystem. Their findings suggest that romosozumab has a significant impact on bone density and offers a promising new treatment option for men battling osteoporosis.

Strengthening Bones: A Desert Oasis of Health

The study shows that romosozumab, like a revitalizing oasis in the desert, can help strengthen bones in men with osteoporosis. After 12 months of treatment, participants receiving romosozumab experienced significant improvements in bone mineral density compared to those receiving a placebo. This discovery is as groundbreaking as finding a hidden spring in the desert.

A Boon for Bone Health

This research provides much-needed hope for men with osteoporosis. Romosozumab offers a potential treatment option that could improve bone health and reduce the risk of fractures. It's a testament to the power of research and the ongoing search for solutions to the challenges we face.

Dr.Camel's Conclusion

This research reveals the potential of romosozumab as a promising new treatment option for osteoporosis in men. The study's findings suggest that romosozumab can significantly improve bone density, offering a beacon of hope for individuals struggling with this condition. While further research is needed, the results provide a glimmer of optimism for men seeking to strengthen their bones and improve their overall health.
Date :
  1. Date Completed 2019-05-28
  2. Date Revised 2019-08-29
Further Info :

Pubmed ID

29931216

DOI: Digital Object Identifier

10.1210/jc.2017-02163

Related Literature

Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.