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Comparative safety of bowel cleansers: protocol for a systematic review and network meta-analysis.

Author: BarbeauPauline, DubeCatherine, HuttonBrian, KanjiSalmaan, MoherDavid, RiceDanielle B, RostomAlaa, SkidmoreBecky, WolfeDianna, YazdiFatemeh

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The US Food and Drug Administration has withdrawn a bowel cleansing kit containing bisacodyl due to an increased risk of ischaemic colitis. This study aims to assess the comparative safety of various bowel cleansers, focusing on polyethylene glycol (PEG)-based and sodium-picosulfate-based products, with or without bisacodyl.
Paper Details　
Original Abstract of the Article :
The US Food and Drug Administration has withdrawn the bowel cleansing kit HalfLytely (PEG 3500) with 10 mg bisacodyl tablets due to an increased risk of ischaemic colitis compared with the same kit with only 5 mg bisacodyl. This is of interest in Canada given that the bowel cleansing kit Bi-Peglyte ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020982/

データ提供：米国国立医学図書館（NLM）

Navigating the Bowel Cleansing Desert: A Systematic Review of Safety

In the vast expanse of medical research, the field of bowel cleansing presents a unique challenge. This systematic review delves into the comparative safety of various bowel cleansers, focusing primarily on polyethylene glycol (PEG)-based and sodium-picosulfate-based products. This is a crucial quest, as the US Food and Drug Administration (FDA) recently withdrew a bowel cleansing kit containing 10 mg bisacodyl due to an increased risk of ischemic colitis. The authors aim to shed light on this safety concern and guide clinicians in selecting the most appropriate bowel cleansing agents. Like a seasoned explorer, they plan to navigate through a vast landscape of clinical data, seeking the most effective and safe pathways for bowel preparation.

Mapping the Safety Landscape of Bowel Cleansers

This systematic review will provide a comprehensive map of the safety landscape of bowel cleansers, highlighting the risks and benefits associated with various products. This information will be crucial for clinicians, helping them make informed decisions regarding the most suitable bowel cleansing regimen for their patients.

Staying Safe in the Bowel Cleansing Desert

While bowel cleansing is often a necessary procedure, it's important to approach it with caution. This study underscores the importance of carefully selecting bowel cleansing agents, considering individual patient factors and potential risks. Consulting with your healthcare provider is essential to ensure the safest and most effective bowel preparation method for you.

Dr. Camel's Conclusion

This systematic review is like a camel caravan meticulously mapping a safe route through the desert of bowel cleansing, focusing on the risks associated with different products. By understanding the comparative safety of various bowel cleansers, clinicians can navigate this complex terrain with confidence and choose the most appropriate path for their patients.
Date :
  1. Date Completed 2019-10-23
  2. Date Revised 2020-03-06
Further Info :

Pubmed ID

29950476

DOI: Digital Object Identifier

PMC6020982

Related Literature

Article Analysis
・Effects of polyethylene glycol 3350
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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