Identification of cisplatin sensitizers through high-throughput combinatorial screening.

Author: ChangAllison, ChenPing, ChiaoPaul J, HuYumin, HuangPeng, JiangWeiye, LingJianhua, LiuKaiyan, LuWenhua, SongMing, SunYichen

Paper Details 
Original Abstract of the Article :
cis-Diamminedichloroplatinum/cisplatin (CDDP) is a major drug used in cancer chemotherapy; however, the toxic side-effects and development of drug resistance represent major challenges to the clinical use of CDDP. The aim of the present study was to identify effective drug combination regimens throu...See full text at original site
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引用元:
https://doi.org/10.3892/ijo.2018.4447

データ提供:米国国立医学図書館(NLM)

Identifying Cisplatin Sensitizers

This study delves into the field of **drug discovery**, exploring the identification of compounds that can enhance the efficacy of cisplatin, a widely used chemotherapy drug. Imagine cancer cells as resilient desert nomads, constantly adapting and evolving to evade the effects of chemotherapy drugs. This research seeks to discover new weapons in the fight against cancer, akin to finding hidden oases with potent medicinal properties.

Combating Drug Resistance Through Combinatorial Screening

The researchers utilized a high-throughput drug screening method to identify compounds that synergistically enhance the effectiveness of cisplatin. This is like combing through a vast desert for hidden treasures, searching for specific combinations of compounds that can effectively target and destroy cancer cells. Their investigation revealed two promising candidates: potassium antimony tartrate and topotecan, demonstrating the potential for combinatorial drug therapy to overcome drug resistance.

Optimizing Cancer Treatment Strategies

This research highlights the potential of high-throughput screening to identify effective drug combinations that can enhance the efficacy of existing chemotherapy drugs. It's like mapping out new routes through the desert of cancer treatment, seeking more effective ways to target and destroy these resilient invaders. The study's findings underscore the importance of ongoing research and development to optimize cancer treatment strategies and improve patient outcomes.

Dr.Camel's Conclusion

This study presents a promising strategy for enhancing the efficacy of cisplatin, a cornerstone of cancer chemotherapy. It's like discovering a new oasis in the vast desert of cancer treatment, offering a potential solution to the challenge of drug resistance. This research underscores the importance of continuous research and development to discover new and more effective approaches to combat cancer.

Date :
  1. Date Completed 2018-11-26
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

29956742

DOI: Digital Object Identifier

10.3892/ijo.2018.4447

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SNS
PICO Info
in preparation
Languages

English

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