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Type 2 NADH Dehydrogenase Is the Only Point of Entry for Electrons into the Streptococcus agalactiae Respiratory Chain and Is a Potential Drug Target.

Author: FranzaThierry, GauduPhilippe, GennisRobert B, IpeDeepak S, LencinaAndrea M, Schurig-BriccioLici A, SullivanMatthew J, UlettGlen C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the respiratory chain of <i>Streptococcus agalactiae</i>, a pathogen causing neonatal meningitis and sepsis. The researchers found that the bacterium uses only one NADH dehydrogenase (NDH-2) and one cytochrome <i>bd</i> oxygen reductase for respiration. NDH-2 is crucial for virulence and could be a target for drug development.
Paper Details　
Original Abstract of the Article :
The opportunistic pathogen <i>Streptococcus agalactiae</i> is the major cause of meningitis and sepsis in a newborn's first week, as well as a considerable cause of pneumonia, urinary tract infections, and sepsis in immunocompromised adults. This pathogen respires aerobically if heme and quinone are...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030563/

データ提供：米国国立医学図書館（NLM）

Streptococcus agalactiae: A Stealthy Pathogen with a Vulnerable Achilles' Heel

The world of [microbiology] is constantly searching for ways to combat [bacterial infections]. This study focuses on [Streptococcus agalactiae], a bacteria that can cause serious infections in both newborns and immunocompromised adults. The researchers investigated the [respiratory chain] of this bacterium, discovering that it relies on a specific enzyme, [type 2 NADH dehydrogenase (NDH-2)], for its survival and virulence. This makes [NDH-2] a potential target for developing new antibacterial therapies.

Targeting NDH-2: A New Strategy to Fight Streptococcus agalactiae Infections

The researchers found that inhibiting [NDH-2] significantly reduced the virulence of [Streptococcus agalactiae]. This is exciting because it suggests that targeting this specific enzyme could be an effective way to control infections caused by this bacterium. Furthermore, the study identified an existing drug, [Zafirlukast], that successfully inhibited [NDH-2] activity, opening the door for repurposing this drug for treating [Streptococcus agalactiae] infections.

A New Frontier in Antibacterial Therapy

Imagine [Streptococcus agalactiae] as a cunning desert nomad, able to adapt and thrive in various environments. [NDH-2] is like the nomad's trusty camel, essential for its survival and ability to travel. By targeting [NDH-2], we can effectively disable the camel, making it much harder for the nomad to survive and spread. This study is a promising step towards developing new and effective antibacterial therapies to combat this dangerous pathogen.

Dr.Camel's Conclusion

This study reveals the critical role of [NDH-2] in the survival and virulence of [Streptococcus agalactiae]. This research opens up new avenues for developing targeted antibacterial therapies, potentially leading to more effective treatments for this challenging infection. The identification of [Zafirlukast] as a potential inhibitor of [NDH-2] is especially exciting, suggesting potential for repurposing existing drugs to combat this pathogen.

Date :
  1. Date Completed 2019-02-12
  2. Date Revised 2019-12-27
Further Info :

Pubmed ID

29970468

DOI: Digital Object Identifier

PMC6030563

Related Literature

Article Analysis
・Side Effects of zafirlukast
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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