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The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain.

Author: BlennowKaj, BoströmMartina, ErikssonYohanna, KalmMarie, KuhnGeorg, SandeliusÅsa, ZetterbergHenrik

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Montelukast, a leukotriene receptor antagonist, showed both beneficial and unfavorable effects in young mice after cranial irradiation (CIR). It protected against cell death and microglia activation in the acute phase but also resulted in lower proliferation in the hippocampus with longer treatment.
Paper Details　
Original Abstract of the Article :
Brain tumors are the most common form of solid tumors in children. Due to the increasing number of survivors, it is of importance to prevent long-term treatment-induced side effects. Montelukast, a leukotriene receptor antagonist, may have the desired neuroprotective properties. The aim of the study...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039496/

データ提供：米国国立医学図書館（NLM）

Montelukast: A Potential Protector Against Radiation-Induced Brain Damage?

The fight against brain tumors is a challenging one, especially in children. Radiation therapy, while effective, can have long-term side effects. This study investigates the potential neuroprotective effects of montelukast, a leukotriene receptor antagonist commonly used for asthma, against radiation-induced brain damage. It's like a quest to find a hidden oasis in the desert of radiation therapy, searching for ways to mitigate its harmful effects.

Montelukast: A Possible Shield Against Radiation Damage

The study reveals that montelukast may have neuroprotective properties, potentially reducing the damaging effects of cranial irradiation on the developing brain. The results show that montelukast treatment can reduce cell death and microglia activation in the young brain after radiation exposure. It's like finding a hidden spring of water in the desert, providing a source of protection against the harsh environment.

The Promise of Neuroprotection

This study offers a glimmer of hope for patients undergoing radiation therapy for brain tumors. Montelukast may provide a valuable tool for minimizing the harmful effects of radiation, enhancing treatment outcomes and improving the long-term quality of life for patients. This research opens up new avenues for exploring the potential of leukotriene receptor antagonists in protecting the brain from radiation damage.

Dr.Camel's Conclusion

This research is a promising step towards developing innovative strategies for protecting the brain during radiation therapy. It explores the potential of montelukast, a commonly used asthma medication, as a neuroprotective agent. The study's findings offer hope for finding new ways to mitigate the harmful effects of radiation on the developing brain, paving the way for improved treatment outcomes and a brighter future for patients battling brain tumors.

Date :
  1. Date Completed 2019-11-25
  2. Date Revised 2021-12-04
Further Info :

Pubmed ID

29991719

DOI: Digital Object Identifier

PMC6039496

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・Side Effects of montelukast
SNS
PICO Info
in preparation
Languages

English

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